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Human Adenovirus-Specific T Cell Response in Kidney Transplant Recipients Diagnosed with Adenovirus Infection

J. Bruminhent1, N. Apiwattanakul2, S. Hongeng3, S. Kantachuvessiri4, S. P. Watcharananan1

1Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 2Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 3Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 4Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Meeting: 2019 American Transplant Congress

Abstract number: B233

Keywords: Adenoviruses, Interferon (IFN), Kidney transplantation, T cells

Session Information

Session Name: Poster Session B: Kidney Infections

Session Type: Poster Session

Date: Sunday, June 2, 2019

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

*Purpose: Cell-mediated immunity plays an important role in controlling human adenovirus (HAdV) infection after kidney transplantation (KT). We investigated T cell lymphocyte subsets and HAdV-specific T cell responses in KT recipients diagnosed with HAdV infection.

*Methods: We conducted a prospective study (January 2015 to June 2018). Interferon (IFN)-γ-producing CD4+ and CD8+ T cells were measured at diagnosis and at viral clearance, by an intracellular cytokine assay after stimulating with HAdV whole lysate, and hexon (HAdV-3) and penton (HAdV-5) proteins.

*Results: Eighteen adult KT recipients were diagnosed with HAdV infection at a median of 16 months (IQR, 2-39 months) after KT. The absolute lymphocyte count at viral clearance was significantly higher compared with diagnosis (2,257 cells/µL [IQR, 1,544-3078] vs. 1,001 cells/µL [IQR, 641-1,385]; p<0.001). Eleven patients underwent measurement of the HAdV-specific T cell response. The median numbers of CD4+ and CD8+ T cells at viral clearance were significantly higher compared with diagnosis (448 vs. 215 cells/µL; p=0.02 and 623 vs. 235 cells/µL; p<0.01, respectively). The median percentages of HAdV-5-specific CD4+ and HAdV-3-specific CD8+ T cells at viral clearance were significantly higher compared with diagnosis (0.012 vs. 0; p=0.03 and 0.136 vs. 0.016; p=0.003, respectively), Figure 1.

*Conclusions: Our findings suggest a trend of HAdV-specific T cell immune restoration in KT recipients who achieve successful viral clearance. Our study supports a potential role of virus-specific T cell immune monitoring to optimize management of HAdV in KT recipients.

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To cite this abstract in AMA style:

Bruminhent J, Apiwattanakul N, Hongeng S, Kantachuvessiri S, Watcharananan SP. Human Adenovirus-Specific T Cell Response in Kidney Transplant Recipients Diagnosed with Adenovirus Infection [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/human-adenovirus-specific-t-cell-response-in-kidney-transplant-recipients-diagnosed-with-adenovirus-infection/. Accessed May 8, 2025.

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