Histopathological Criteria for Elevated Risk of Delayed Graft Function in German Pretransplantation Kidney Biopsies from Deceased Donors
1Institute of Pathology, University Hospital of Cologne, Cologne, North Rhine-Westfalia, Germany
2Deutsche Stiftung Organtransplantation, Frankfurt, Hesse, Germany
3Department of Nephrology and Hypertension, Diabetology and Endocrinology, University Hospital of Magdeburg, Magdeburg, Saxonia-Anhalt, Germany
4Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Lower Saxony, Germany.
Meeting: 2015 American Transplant Congress
Abstract number: C54
Keywords: Biopsy, Cadaveric organs, Donors, Kidney transplantation, marginal
Session Information
Session Name: Poster Session C: ECD/DCD/high KDPI
Session Type: Poster Session
Date: Monday, May 4, 2015
Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
Introduction:
Delayed graft function (DGF) is more frequent with so called marginal kidney donors. Moreover, it is linked to increased recipient mortality and inferior transplant outcome. We tested correlations between histopathological findings from German pretransplantation biopsies of deceased kidney donors and delayed graft function, serum creatinine at 3 months and 1 year after transplantation.
Material and Methods:
A total of 58 pretransplant biopsies, 39 from recipients with DGF and 19 from recipients without were evaluated for Banff components and various histopathological sum scores reflecting chronic vascular damage, scarring, inflammation and acute tubular damage.
Results from these scores were correlated with DGF and serum creatinine at 3 months and 1 year after transplantation. Nonparametric tests were used for comparison, results were considered significant with p<0.05 in two-sided tests.
Results:
The pretransplant biopsies' Remuzzi score and percentage of glomeruli with global glomerulosclerosis were lower in transplants with DGF than without.
No significant correlation was found between serum creatinine 3 months after transplantation and the histological scores.
The pretransplant biopsies' chronic vascular Banff sum score (cv+ah), the chronic Banff sum score (cv+cg+ci+ct+ah+mm) and the Remuzzi score correlated with serum creatinine 1 year after transplantation.
Conclusion:
Our data question the usefulness of the Remuzzi score and the percentage of global glomerulosclerosis for the prediction of DGF in German pretransplantation biopsies from deceased donors.
In particular chronic vascular changes as reflected in the Banff components cv and ah seem to indicate an inferior graft function one year after transplantation, whereas the percentage of global glomerulosclerosis or tubulointerstitial scarring seem to be of minor importance.
To cite this abstract in AMA style:
Becker J, Eggers B, Mertens P, Schwarz A, Chatzikyrkou C. Histopathological Criteria for Elevated Risk of Delayed Graft Function in German Pretransplantation Kidney Biopsies from Deceased Donors [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/histopathological-criteria-for-elevated-risk-of-delayed-graft-function-in-german-pretransplantation-kidney-biopsies-from-deceased-donors/. Accessed May 31, 2025.« Back to 2015 American Transplant Congress