Free Fatty Acids and Delayed Graft Function after Kidney Transplantation: A Single Center Analysis

J. Zhou¹, J. Lyu¹, X. Yu¹, C. Wu², J. Chen¹

¹The First Affiliated Hospital Kidney Disease Center, College of Medicine, Zhejiang University, Hangzhou, China, ²Global Health Research Center, Duke Kunshan University, Kunshan, China

Meeting: 2020 American Transplant Congress

Abstract number: C-061

Keywords: Kidney transplantation, Lipids, Risk factors

Session Information

Session Name: Poster Session C: Kidney Complications: Non-Immune Mediated Late Graft Failure

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: Delayed graft function (DGF) is one of the most common obstacles of donation after circulatory death (DCD) kidney transplantation. Serum free fatty acids (FFAs) has been proved to be related with inflammation and immunomodulation. But its role in kidney transplantation has not been fully studied.

*Methods: General data of recipients undergoing DCD kidney transplantation from July 25, 2017 to July 24, 2018 in our center were collected. FFAs pre-transplantation were analyzed.

*Results: There were 26 recipients developed DGF among 214 patients included. DGF patients experienced prolonged hospitalization and more complications (P < 0.050). Worse graft functions at hospital discharge and 1-year post-operation were noted in DGF group (P = 0.001). DGF group had higher levels of serum homocysteine (Hcy), FFAs, serum uric acid (UA) (P < 0.050). FFAs was a risk factor for onset of DGF (P < 0.001, value of area under ROC curve: 0.925 (0.856-0.994)), and serum creatinine (SCr) level at hospital discharge was a risk factor for poor outcomes of DGF patients (P = 0.040).

*Conclusions: DGF onset can be predicted by FFAs pre-transplantation. The internal mechanisms between FFAs and DGF need to be further explored by the next experimental studies.

To cite this abstract in AMA style:

Zhou J, Lyu J, Yu X, Wu C, Chen J. Free Fatty Acids and Delayed Graft Function after Kidney Transplantation: A Single Center Analysis [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/free-fatty-acids-and-delayed-graft-function-after-kidney-transplantation-a-single-center-analysis/. Accessed November 22, 2024.

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