Felodipine Diminishes Decline in Glomerular Filtration Rate in Lung Transplanted Patients Treated with Cyclosporine: A Randomized Placebo Controlled Trial.
1Nephrology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
2Cardiology, Section for Lung Transplantation, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
3Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
4Cardiothoracic Anaesthesiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
5Public Health, Section of Biostatics, University of Copenhagen, Copenhagen, Denmark
6Cardiothoracic Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Meeting: 2017 American Transplant Congress
Abstract number: B242
Keywords: Calcineurin, Immunosuppression, Post-operative complications, Renal dysfunction
Session Information
Session Name: Poster Session B: Lung Transplantation Poster Session
Session Type: Poster Session
Date: Sunday, April 30, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Background. Calcium channel blockers may ameliorate the decline in renal function caused by calcineurin inhibitors in lung transplant (LTX) recipients. We previously demonstrated a 47 ml/min decline in glomerular filtration rate 12 weeks after LTX and a 22% incidence of ESRD after 10 years in LTX patients
Methods. In this double-blind study we randomly assigned 41 patients with end stage lung disease and normal kidney function to receive placebo (20 patients) or felodipine (21 patients) started preoperatively and titrated to 10 mg or maximum tolerable dose. Only patients above the age of 18 and on the waiting list for pulmonary transplantation were eligible for inclusion. The primary endpoint was the change in renal function as measured by glomerular filtration rate using Cr-51 labelled ethylenediamine tetraacetic acid from transplantation to 12 weeks hereafter.
Results. Treatment with felodipine resulted in a 35% lesser decrease in GFR compared to placebo (16.8 ml/min/1.73m2 (95% CI: 4.3-29.3 ml/min; 31.3±19.0 ml/min/1.73m2 and 48.1±18.4 ml/min/1.73m2 respectively, P=0.01)). Hypotension occurred more frequently among felodipine-treated patients compared with placebo (P<0.01). Blood pressure control assessed by systolic blood pressure at 3 weeks improved in patients treated with felodipine during the study period (P=0.048). Body weight did not differ significantly in the two groups during the study.
Conclusions. Compared with placebo, felodipine ameliorated the initial decline in GFR caused by calcineurin inhibitors after lung transplantation.
CITATION INFORMATION: Hornum M, Iversen M, Oturai P, Andersen M, Zemtsovski M, Bredahl P, Bjarnason N, Christiansen K, Carlsen J, Møller C, Feldt-Rasmussen B, Perch M. Felodipine Diminishes Decline in Glomerular Filtration Rate in Lung Transplanted Patients Treated with Cyclosporine: A Randomized Placebo Controlled Trial. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Hornum M, Iversen M, Oturai P, Andersen M, Zemtsovski M, Bredahl P, Bjarnason N, Christiansen K, Carlsen J, Møller C, Feldt-Rasmussen B, Perch M. Felodipine Diminishes Decline in Glomerular Filtration Rate in Lung Transplanted Patients Treated with Cyclosporine: A Randomized Placebo Controlled Trial. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/felodipine-diminishes-decline-in-glomerular-filtration-rate-in-lung-transplanted-patients-treated-with-cyclosporine-a-randomized-placebo-controlled-trial/. Accessed May 12, 2025.« Back to 2017 American Transplant Congress