Favorable Long-Term Prognosis of Hepatitis B Surface Antigen Positive Intrahepatic Cholangiocarcinoma for Both Hepatic Resection and Incidental Liver Transplantation via Inhibiting Cancer-Associated Lymphangiogenesis.
Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Meeting: 2017 American Transplant Congress
Abstract number: A86
Keywords: Hepatitis B, Liver transplantation, Lymph node
Session Information
Session Name: Poster Session A: Clinical Science: Liver - Hepatocellular Carcinoma and Cholangiocarcinoma Malignancies
Session Type: Poster Session
Date: Saturday, April 29, 2017
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall D1
Background: In recent years, a few publications indicated that hepatitis B virus (HBV) infection is associated with the prognosis of patients with ICC after resection. However, due to conflicting results and scant evidence, the impact of HBV infection on ICC still remains unclear.
Methods: We reviewed the clinicopathological characteristics of ICC patients and carried out overall and relapse-free survival analyses to identify prognostic factors. The patients were stratified according to the current, past, and those without a history of HBV infection to specify the impact of HBV infection on ICC. We also performed immunohistochemical and immunofluorescent staining on serial sections to evaluate the extent of lymphangiogenesis.
Results: HBV infection, type of surgery, and lymph node metastasis were found to be independent prognostic factors for patients with ICC. Contrary to previous publications, we found that only current HBV infection was associated with a relatively more favorable prognosis for patients of both hepatic resection and incidental liver transplantation (LT). There were significant differences between HBsAg-positive and negative ICC patients in age, gender distribution, the incidence of liver cirrhosis, AFP elevation, and lymph node metastasis. Microlymphatic vessel density and lymphatic endothelial-like structures were significantly decreased in HBsAg-positive ICC patients.
Conclusion: Put together, our findings provide new insight to the application of HBsAg seropositivity as a novel predictor for patient prognosis and indicate that suppressed lymphangiogenesis in HBsAg-positive ICC may be a new approach that could influence the current understanding of LT for ICC.
CITATION INFORMATION: Gu J, Jeong S, Sha M, Zhang J, Xia Q. Favorable Long-Term Prognosis of Hepatitis B Surface Antigen Positive Intrahepatic Cholangiocarcinoma for Both Hepatic Resection and Incidental Liver Transplantation via Inhibiting Cancer-Associated Lymphangiogenesis. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Gu J, Jeong S, Sha M, Zhang J, Xia Q. Favorable Long-Term Prognosis of Hepatitis B Surface Antigen Positive Intrahepatic Cholangiocarcinoma for Both Hepatic Resection and Incidental Liver Transplantation via Inhibiting Cancer-Associated Lymphangiogenesis. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/favorable-long-term-prognosis-of-hepatitis-b-surface-antigen-positive-intrahepatic-cholangiocarcinoma-for-both-hepatic-resection-and-incidental-liver-transplantation-via-inhibiting-cancer-associated-l/. Accessed May 13, 2025.« Back to 2017 American Transplant Congress