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Excessive Weight Gain Does Not Associate with Poorer Graft Outcomes in Simultaneous Pancreas-Kidney Transplant Recipients – A Single-Center Experience

N. Eleti, G. Agarwal, S. Ong, C. Kew, D. Anderson, C. Young

University of Alabama at Birmingham, Birmingham, AL

Meeting: 2022 American Transplant Congress

Abstract number: 1170

Keywords: Graft failure, Kidney/pancreas transplantation, Outcome, Weight

Topic: Clinical Science » Pancreas » 65 - Pancreas and Islet: All Topics

Session Information

Session Name: Pancreas and Islet: All Topics

Session Type: Poster Abstract

Date: Sunday, June 5, 2022

Session Time: 7:00pm-8:00pm

 Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: Weight gain is common following organ transplantation, and there exists concern that in simultaneous pancreas-kidney (SPK) recipients, this may lead to poorer graft outcomes.

*Methods: We reviewed data from 61 consecutive patients with type 1 diabetes mellitus who received SPK transplants between January 1st, 2012, and December 31st, 2017, to study excessive weight gain in these patients, and the subsequent effect on graft outcomes. Weight, and other outcomes were followed up until November 30th, 2021. Excessive weight gain (EWG) was defined as an increase of > 20% in weight following transplant. Statistical analysis was performed with R.

*Results: Patient characteristics were as follows: 65% male, 67% Caucasian, 19% African American. At transplant, median age was 39 years, body mass index (BMI) was 24.08 kg/m2. 29 patients (48%) experienced organ rejection (7 kidney rejection alone, 8 pancreas alone, 14 both organs). 14 patients (23%) experienced graft loss (5 pancreas alone, 3 kidney alone, 7 both organs). EWG at 1, 3, and 5 years occurred in 18%, 21%, and 13% of patients respectively. Univariate analysis showed that age at transplant, BMI at transplant, age <, or > 40 years, gender, race, rejection, and steroid use was not associated with excessive weight gain at 1 year post-transplant. At 3 years, African American race, and organ rejection were associated with EWG (p=0.019, and 0.05 respectively). At 5 years, only African American race was associated with EWG (p-=0.003). Of the variables studied, only organ rejection was associated with kidney and pancreas allograft loss, while other variables, including EWG at 1, 3, or 5 years were not. Mean BMIs at transplant, 1 year, 3 years and 5 years post-transplant were 24.1, 25.4, 26.0, 26.5 kg/m2 respectively.

*Conclusions: At five years of follow-up, most patients did not have EWG. EWG did not increase the risk of graft loss.

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To cite this abstract in AMA style:

Eleti N, Agarwal G, Ong S, Kew C, Anderson D, Young C. Excessive Weight Gain Does Not Associate with Poorer Graft Outcomes in Simultaneous Pancreas-Kidney Transplant Recipients – A Single-Center Experience [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/excessive-weight-gain-does-not-associate-with-poorer-graft-outcomes-in-simultaneous-pancreas-kidney-transplant-recipients-a-single-center-experience/. Accessed May 9, 2025.

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