Introduction: There continues to be much debate whether Type II diabetics can benefit from a SPK. We are reporting our 20 years experience in patients with end stage renal disease and diabetes mellitus who received a SPK transplant.
Methods: 173 Patients with end stage renal disease secondary to diabetes mellitus received a SPK transplant between 1989 and 2008, and were stratified by diabetes type.
Results: Refer to table I for patient characteristics. Type II diabetics had better graft survival than Type I diabetics, p=0.032; while Type I patients, had better patient survival than Type II patients (p=0.045).
|Type I (N=115)||Type II (N=58)||P-Value|
|DM Age of Onset||15.14 (±7.58)||24.2 (±10.54)||P<0.0001|
|Age of Transplant||38.5 (±7.96)||42.8 (±8.40)||P=0.0012|
|Mean C-Peptide||0.33 (±0.2)||5.34 (±3.66)||P<0.0001|
|Pre Transplant BMI||23.1 (±3.4)||26.09 (±4.4)||P<0.0001|
|Post Transplant BMI||24.7 (±4.7)||29.7 (±6.3)||P<0.0001|
|Years Maintained on Insulin||22.5 (±7.16||19.19 (±7.08)||P=0.012|
|Recipient's Race||41.7% African American||68.9% African American||P=0.007|
Conclusion: Previous data had demonstrated that there were no differences at 5, 10, and 15 years post transplant. However, there appears to some differences at the 20 year follow-up. Type II patients had better graft survival, while Type I patients had better patient survival, which may be an indication at the age when patients were transplanted. Future studies should be conducted to follow long term follow-up and ascertain if those noted differences were true and not secondary to intrinsic population variables.
To cite this abstract in AMA style:Light J, Tucker M, Orquiza M. Evolution of SPK Transplant in Type I and Type II Diabetics with End Stage Renal Disease: The 20 Year Experience, The [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/evolution-of-spk-transplant-in-type-i-and-type-ii-diabetics-with-end-stage-renal-disease-the-20-year-experience-the/. Accessed July 12, 2020.
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