ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Donor Derived Transmissions 2018: Analysis of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC)

M. Michaels1, B. Plucinski2, E. Ward2, L. Strasfeld1, M. Malinis1, C. Ho1, L. Danziger-Isakov1, J. Bucio1, G. Berry1, M. Rana1, C. Marboe1, S. Aslam1, R. Razonable1, S. Pouch1, G. F. Marklin1, J. Levitsky1, D. Levine1, A. Agarwal1, R. LaHoz1

1OPTN DTAC, Richmond, VA, 2UNOS, Richmond, VA

Meeting: 2020 American Transplant Congress

Abstract number: 165

Keywords: Donation, Infection, Malignancy, Outcome

Session Information

Session Name: Donor Derived Infections

Session Type: Oral Abstract Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:45pm

 Presentation Time: 3:15pm-3:27pm

Location: Virtual

*Purpose: The OPTN DTAC, a multidisciplinary group, evaluates potential donor derived transmission events (PDDTE), mostly infections (I) & malignancies (M), to assess the likelihood of disease transmission.

*Methods: This is a retrospective study of PDDTE cases reported to the OPTN between 01/18 and 12/18. DTAC reviewed cases using a standardized classification algorithm.

*Results: During 2018, there were 17,570 donors and 36,529 recipients. DTAC reviewed 256/276 cases reported. 55 /256 (21.5%) donors had proven/probable (P/P) transmission of I, M or other conditions to 77 /172 (44.8%) exposed recipients [figure]. 9 involved living donors. Infections made up 36/55 P/P cases affecting 50 recipients. Viruses caused the most frequent P/P infections; 16 recipients from 12 donors had P/P transmission. HBV & HCV accounted for 28 of the 48 virus reports; 7 recipients had P/P transmissions from 6 donors. Parasites (49 reports) resulted in 8 donors transmitting to 8 recipients with 2 attributable deaths. 12 donors with malignancies were classified as P/P; 17 impacted recipients and ultimately 7 attributable deaths. 24 non-I, non-M PDDTE were also reported; 7 resulted in P/P transmissions to 10 recipients. Deaths from infection (N=6) occurred a median of 50 days (30-113 days), whereas deaths from malignancy (N=7) occurred a median of 95 days (47-176 days).

*Conclusions: Although P/P events remain rare, 1/5 reported cases resulted in unanticipated P/P transmission. This is a conservative estimate; some recipients received an intervention to ameliorate risk and the reporting system is passive. Infections were the most commonly reported event. Lung recipients appear disproportionately represented in this cohort and may have increased risk for donor derived transmission events. Donor-derived malignancy, while uncommon, carries a significant mortality. The DTAC continues to evaluate PDDTE to maximize organ use and assess preventative strategies to minimize risk of transmission.

 border=

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Michaels M, Plucinski B, Ward E, Strasfeld L, Malinis M, Ho C, Danziger-Isakov L, Bucio J, Berry G, Rana M, Marboe C, Aslam S, Razonable R, Pouch S, Marklin GF, Levitsky J, Levine D, Agarwal A, LaHoz R. Donor Derived Transmissions 2018: Analysis of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC) [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/donor-derived-transmissions-2018-analysis-of-the-optn-ad-hoc-disease-transmission-advisory-committee-dtac/. Accessed May 10, 2025.

« Back to 2020 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences