Does Living Donor–Recipient Age Difference Matter in Long Term Outcome of Kidney Transplantation? Implication for Kidney Paired Donation
IKDRC-ITS, Ahmedabad, Gujarat, India
Meeting: 2013 American Transplant Congress
Abstract number: 340
Background
Kidney Paired Donation (KPD) is a rapidly growing modality for facilitating living donor renal transplantation (LDRTx) for patients who are incompatible with their healthy living donors.
In a proposed KPD match, if an old donorrecipient pair is matched to a younger donorrecipient pair, young recipient may feel disadvantaged and therefore may be unwilling for exchange with an older donor. Refusal to participate in an exchange could limit the success of KPD program when donor pool is small.
Material and Methods
This was a single center study of 1502 patients on regular follow-up, who underwent LDRTx from 1999 to 2012. Donorrecipient age difference was divided into two groups group1 with 0-20 years difference (n=705) and group 2 (n=797) with 21- 40 years difference.
Donor Recipient Age Difference 0-20 (n=705) | Donor Recipient Age Difference 21-40 (n=797 | P value | |
Age (Recipient) yr | 33.9±9.2 | 24.9±6.9 | 0.0001 |
Male gender (Recipient) | 578 | 665 | 0.457 |
Age (Donor) yr | 44.9±9.44 | 51.7±7.41 | 0.0001 |
male gender (Donor) | 243 | 261 | 0.481 |
Outcome measures included graft survival, patient survival and rejection rates.
Results
One, five and ten- year patient survival (Figure 1) showed no significant difference between the 2 groups (94.5%, 83.2%, 71.9% vs. 95.2%, 86%, 77.8%, p 0.053).
Graft survival (Figure 2) also showed no significant difference (94.6%, 81.6%, 72.1% vs. 94%, 80%, 72.2%, p 0.989).
Acute and chronic rejection incidence were also similar (17.5% vs 16.5%, p >0.86; and 7.8% vs 6.8%, p 0.44).
Conclusions
The age of a donor has little impact on the survival of transplanted kidney. Results of this study could persuade more people to take part in KPD programs. This study is important for policy/decision making in KPD when donor pool is limited.
To cite this abstract in AMA style:
Kute V, Vanikar A, Gumber M, Patel H, Shah P, Engineer D, Modi P, Rizvi J, Shah V, Trivedi H. Does Living Donor–Recipient Age Difference Matter in Long Term Outcome of Kidney Transplantation? Implication for Kidney Paired Donation [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/does-living-donorrecipient-age-difference-matter-in-long-term-outcome-of-kidney-transplantation-implication-for-kidney-paired-donation/. Accessed October 10, 2024.« Back to 2013 American Transplant Congress