Does BMI Affect Survival in Cadaveric Liver Transplantation for Benign Conditions?
Surgery, Dalhousie University, Halifax, NS, Canada.
Meeting: 2015 American Transplant Congress
Abstract number: C128
Keywords: Liver transplantation, Obesity, Survival
Session Information
Session Name: Poster Session C: Liver Donation and Allocation
Session Type: Poster Session
Date: Monday, May 4, 2015
Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
Obesity is a relative contraindication to liver transplantation (LT). Aim of this study was to analyze morbidity, mortality, long-term survival of cadaveric LTs stratified by BMI using SRTS data
Methods Adult recipients of LT for benign conditions (April 1994-June 2013) were included. BMIs were categorized by WHO classification. Two-tailed P values less than 0.05 were considered significant
Results Patients characteristics are reported in table 1. 30day mortality occurred in 11.5% of underweight patients, 10% in normal weight, 10.2% in overweight, 11.5% in class I, 13% in class II, 16.3% in class III obese patients and in 16.3% of recipients with BMI>45 (P=0.0001). Unadjusted survival revealed that normal weight patients (median survival 176 months;95% CI 170.5-181.4) had better survival in comparison to underweight patients (145months;P=0.0001), class II obese (157months;P=0.04), class III (153months;P=0.03) and patients with BMI>45 (133months;P=0.01). Survival analysis showed a significant improvement for all BMI classes transplanted after 2002 except for underweight patients (P=0.016)(Figure 1)
Conclusions Obesity is not a predictor for inferior survival in LT recipients transplanted after 2002. On the other hand, underweight status remains a significant risk factor for perioperative mortality and lowere 5-year survival
| Variable | Frequency, Mean | SD, (%) |
| Age, years (Mean, SD) | 51.8 | 10,3 |
| Gender, Males (N, %) | 32,531 | 62,7 |
| Primary Cause of Liver Failure (N, %) | ||
| Alcohol | 8,662 | 16.70% |
| HCV | 13,996 | 27.00% |
| PBC | 2,562 | 4.90% |
| PSC | 1,292 | 2.50% |
| NASH | 2,516 | 4.80% |
| Cryptogenic | 3,158 | 6.10% |
| Autoimmune | 1,893 | 3.50% |
| BMI (Mean, SD) | 28 | 5.7 |
| Underweight (BMI<18.5) | 1,094 | 2.10% |
| Normal Weight (BMI 18.5-24.99) | 15,809 | 30.50% |
| Overweight (BMI>25) | 17,865 | 34.40% |
| Obesity Class I (BMI 30-34.99) | 10,592 | 20.40% |
| Obesity Class II (BMI 35-39.99) | 4,695 | 9.00% |
| Obesity Class III (BMI>40) | 1,828 | 3.50% |
| Patients with BMI>45 | 289 | 0.60% |
| MELD score | 24.7 | 9.7 |
To cite this abstract in AMA style:
Ayloo S, Hurton S, Cwinn M, Kavanagh R, Molinari M. Does BMI Affect Survival in Cadaveric Liver Transplantation for Benign Conditions? [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/does-bmi-affect-survival-in-cadaveric-liver-transplantation-for-benign-conditions/. Accessed May 17, 2025.« Back to 2015 American Transplant Congress