*Purpose: Disparities in outcomes of hepatocellular carcinoma (HCC) have not been adequately studied, especially in the context of liver transplantation (LT). We sought to identify disparities in racial/ethnic groups in this patient population with the goal to find ways to mitigate them.

*Methods: We obtained patient and tumor characteristics from the National UNOS STAR files from April 12, 2012 to June 6, 2021. One-way ANOVA and Chi-square tests were conducted looking for differences among racial/ethnic groups, utilizing non-Hispanic White (NHW) patients as the comparator. A p-value of &lt.05 was deemed significant. All statistical analysis was performed using SAS 9.4

*Results: Mean graft and patient survival times were the lowest in Hispanics among all groups. Hispanics also had the highest MELD at listing in the recipient and waitlist groups. Among LT recipients, Non-Hispanic Blacks (NHBs) had significantly lower MELDs at listing and transplant compared to NHW. In Hispanics age, MELD at listing, MELD at transplant, graft survival, patient survival, and tumor necrosis were all significantly different from NHW. In the Asian population significant differences were seen in age, sex, BMI, MELD at listing and transplant, graft status, tumor necrosis, tumor differentiation, and vascular invasion. For patients dropped from the waitlist, Hispanics constituted higher proportions of death on the list and worsened condition.

*Conclusions: There are significant disparities in the Hispanic population compared to NHW with regard to waitlist and transplant outcomes in HCC in the United States. Whether these are a result of the recognized increased proportion of NASH diagnosis among Hispanics or the effect of socioeconomic factors will need closer evaluation

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