ATC Abstracts

American Transplant Congress abstracts

Diabetes Mellitus and Kidney Transplant Outcomes.

1Nephrology, University of California-Los Angeles, Los Angeles, CA
2Internal Medicine, Albert Einstein University, Bronx, NY.

Meeting: 2016 American Transplant Congress

Abstract number: D272

Keywords: , ,

Session Information

Session Name: Poster Session D: Poster Session II: Kidney Complications-Other

Session Type: Poster Session

Date: Tuesday, June 14, 2016

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Background:

This study investigates the impact of pre-existing (PDM) and new onset diabetes (NODAT) on the graft and patient survival after kidney transplant.

Methods:

The UNOS database was used to identify adults (age>= 18) who underwent kidney transplants between January 1, 2004 and December 31, 2010.

A historical cohort study with 75,986 recipients (age>18 years; 2004-2010) surviving with a functioning transplant for longer than 1 year were identified using the Organ Procurement and Transplant Network/United Network for Organ Sharing database. Recipients were stratified into 3 mutually exclusive groups according to their diabetic status: Non-Diabetic; new-onset diabetes reported within the first transplant year (NODAT); and history of pretransplant diabetes mellitus (PDM). Median follow-up was 1453 days (25th-75th percentiles; 1019-2110 days) after the first post-transplant year. Multivariate stepwise cox regression were used to analyze the relative risks for the outcomes of transplant failure and patient mortality.

Results:

Hazard ratios are reported in

  Overall Transplant Failure Death-Censored Transplant Failure
  Unadjusted HR Adjusted HR Unadjusted HR Adjusted HR
Neither Reference Reference Reference Reference
PDM

1.57

1.52-1.62

1.44

1.39-1.49

1.01

0.95-1.05

1.13

1.07-1.19
NODAT

1.23

1.16-1.32

1.08

1.02-1.16

1.08

0.99-1.18

1.01

0.93-1.10

and

  Patient Mortality
Unadjusted HR Adjusted HR
Neither Reference Reference
PDM

2.54

2.43-2.66

1.87

1.78-1.96
NODAT

1.49

1.36-1.63

1.19

1.09-1.31

.

Kaplan Meier survival estimates for transplant outcomes are shown in .

CITATION INFORMATION: Mehrnia A, Wang A, Chaiwatcharayut W, Huang E, Bunnapradist S. Diabetes Mellitus and Kidney Transplant Outcomes. Am J Transplant. 2016;16 (suppl 3).

To cite this abstract in AMA style:

Mehrnia A, Wang A, Chaiwatcharayut W, Huang E, Bunnapradist S. Diabetes Mellitus and Kidney Transplant Outcomes. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/diabetes-mellitus-and-kidney-transplant-outcomes/. Accessed November 22, 2024.

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