Session Type: Poster Session
Date: Saturday, May 30, 2020
Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
*Purpose: Increased rates of delayed graft function (DGF) have been reported in the recipients of simultaneous liver and kidney (SLK) transplant. However, the effect of DGF on long-term kidney allograft are controversial. This study aims to determine the variables associated with DGF in patients with SLK transplant and its effect on the long-term kidney allograft outcomes.
*Methods: We analyzed the records of consecutive SLK recipients transplanted at our university hospital between 2010 and 2017.
*Results: We identified 60 SLK recipients during this period with a mean post transplant follow up of 4 ± 2.6 years. The overall incidence of DGF after SLK transplant was 47% (n=28). Multivariate analysis showed that pre-transplant dialysis > 6 weeks (HR=5.6, 95%Cl 1.23 to 25.59, p=0.02), pre-transplant albumin < 3 mg/dl (HR=5.75, 95%Cl 1.81 to 18.23, p=0.003), presence of pre-transplant diabetes (HR=2.5, 95%Cl 1.06 to 5.86, p=0.03) and donor after cardiac death (DCD) (HR=0.36, 95%Cl 0.13 to 0.97, p=0.04) were significant associated with post-transplant DGF. In the univariate analysis showed DGF (HR= 2.62, 95%Cl 0.96 to 7.15, p=0.05), Age > 55 years at time of transplant (HR=3.09 , 95%Cl 0.88 to 10.81, p=0.04), male sex (HR= 0.31, 95%Cl 0.11 to 0.84, p = 0.02) and pre-transplant albumin < 3 mg/dl (HR= 4.86, 95%Cl 1.07 to 21.98, p=0.04) were associated with increased kidney allograft loss or death, however only male sex (HR=0.32 , 95%Cl 0.11 to 0.87, p=0.03) was associated with the higher risk of graft loss or death in the multivariate analysis.
*Conclusions: Although our study was limited by a smaller sample size, we found that the incidence of DGF was high. However, with proper management, DGF didn’t have negative impact on the patient or graft survival.
To cite this abstract in AMA style:Aziz F, Muth B, Garg N, Mohamed M, Mandelbrot D, Mezrich J, Djamali A, Parajuli S. Delayed Graft Function in the Recipients of Simultaneous Liver and Kidney Transplant: A Single-Center Experience [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/delayed-graft-function-in-the-recipients-of-simultaneous-liver-and-kidney-transplant-a-single-center-experience/. Accessed December 1, 2023.
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