ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Covid-19 in Solid Organ Transplantation (SOT): Results of the National Covid Cohort Collaborative (N3C)

G. Agarwal1, A. Vinson2, R. Dai3, E. French4, S. Lee5, A. Olex4, A. Anzalone6, V. Madhira7, R. B. Mannon8

1Medicine, University of Alabama at Birmingham, Birmingham, AL, 2Medicine/Nephrology, Nova Scotia Health Authority, Halifax, NS, Canada, 3Biostatistics, University of Nebraska Medical Center, Omaha, NE, 4Wright Center for Clinical and Translational Research, VIrginia Commonwealth University, Richmond, VA, 5Medicine/Infectious Disease, University of Saskatchewan, Saskatoon, SK, Canada, 6Neurology, University of Nebraska Medical Center, Omaha, NE, 7Palia Software, Not sure, OR, 8Medicine/Nephrology, University of Nebraska Medical Center, Omaha, NE

Meeting: 2021 American Transplant Congress

Abstract number: 126

Keywords: Infection, Morbidity, Outcome, Renal failure

Topic: Clinical Science » Infectious Disease » All Infections (Excluding Kidney & Viral Hepatitis)

Session Information

Session Name: COVID-19 Session 2

Session Type: Rapid Fire Oral Abstract

Date: Sunday, June 6, 2021

Session Time: 4:30pm-5:30pm

 Presentation Time: 5:05pm-5:10pm

Location: Virtual

*Purpose: SARS-CoV-2 infection has resulted in significant mortality in solid organ transplant (SOT) recipients based on reports from single centers or voluntary registries. The N3C Enclave was developed to facilitate analysis of patient-level data across the US for multiple conditions, consisting of weekly electronic medical record (EMR) data extraction and transmission into a federally secured platform. Herein is our report of the largest cohort of US COVID-19 positive SOT patients to date.

*Methods: We identified a cohort of SOT recipients who received a positive or negative COVID-19 test (COVID+ and COVID–, respectively) between 01/01/2020 and 11/23/2020. In COVID+ SOT, we evaluated outcomes including requirement for hospitalization, major adverse cardiac events (MACE), and graft rejection and failure occurring until study end. Significant differences between COVID+ and COVID– patients were identified using t-test and chi-square testing, as indicated.

*Results: 34 sites account for 2.15 million patients in the Enclave, of whom 292,226 are COVID+. We identified 19,031 SOT patients, of whom 2,183 were COVID+ (11.5%) with a median follow-up time of 119 days. Demographics are shown in Figure 1. Compared to COVID– SOT patients, COVID+ SOT patients were more likely to have a kidney transplant and be non-white or Hispanic. Hypertension, diabetes, coronary artery disease and chronic kidney disease were common comorbidities in all SOT, but significantly more common in those who were COVID+. Of COVID+ SOT, 51.8% required hospital admission for a median of 1 days (range 0-114). Following COVID diagnosis, 13.7% of COVID+ SOT patients experienced MACE, 3.8% had graft rejection and 3.4% had graft loss over the study period.

*Conclusions: In the largest US cohort of COVID+ SOT recipients to date, we identify patient factors associated with the diagnosis of COVID-19 and outcomes following infection including a relatively high incidence of MACE. This is an evolving dataset and provides novel opportunities for analyses of COVID in SOT recipients on a granular level.

 border=

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Agarwal G, Vinson A, Dai R, French E, Lee S, Olex A, Anzalone A, Madhira V, Mannon RB. Covid-19 in Solid Organ Transplantation (SOT): Results of the National Covid Cohort Collaborative (N3C) [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/covid-19-in-solid-organ-transplantation-sot-results-of-the-national-covid-cohort-collaborative-n3c/. Accessed May 9, 2025.

« Back to 2021 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences