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Comparison of Microvascular Inflammation in Renal Allograft Tissue between ABO Incompatible and ABO Compatible Kidney Transplantation

E. Ko,1,2 B. Choi,1,2 C. Park,1,2 Y. Kim,1,2 C. Yang,1,2 B. Chung.1,2

1Transplant Research Center, College of Medicine, Seoul St.Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea
2Division of Nephrology, Department of Internal Medicine, College of Medicine, Seoul St.Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

Meeting: 2018 American Transplant Congress

Abstract number: A111

Keywords: Kidney, Rejection

Session Information

Session Name: Poster Session A: Kidney Acute Antibody Mediated Rejection

Session Type: Poster Session

Date: Saturday, June 2, 2018

Session Time: 5:30pm-7:30pm

 Presentation Time: 5:30pm-7:30pm

Location: Hall 4EF

Background: Microvascular inflammation (MVI) is considered as a pathological marker for antibody-mediated rejection (AMR) in the presence of donor-specific antibody (DSA). We aimed to investigate clinical role of MVI as predicting AMR in ABO incompatible kidney transplantation. (ABOi KT)

Material and Methods: A single-center retrospective matched cohort study was conducted. We evaluated histologic parameters in kidney biopsy of 296/75 ABO compatible (ABOc)/ABO incompatible (ABOi) consecutive living donor KT, matched for donor age and transplantation year. In the ABOi group, the desensitization protocol consisted of rituximab, plasmapheresis and immunoglobulins.

Results: Between ABOc and ABOi group, there was no difference in death-censored graft survival, and patient survival. (p-values for each 0.068. and 0.294) The cumulative incidence of acute rejection determined by both protocol biopsy and indication biospies was 19.5% and 23.2% (p=0.515) There was no difference in the incidence of MVI between ABOi KT and ABOc KT. (p=0.284) The incidence of MVI at protocol biopsy on post KT 3 months were not statistically different between ABOi and ABOc group. (p=0.103) High titer of Anti-A/B antibody didn't correlated with the risk of MVI. (p=0.689) When compare ABOi KT to human leukocyte antigen (HLA) sensitized KT, highly-HLA-sensitized group (DSA Luminex MFI >5,000 or Pannel reactive antibody (PRA)>50%) showed tendency of increased rejection rate compared to low-sensitized group, despite of statistically insignificance. (p=0.311) And highly sensitized ABOi group had more frequently incidence of MVI than low-sensitized group (p<0.001).

Conclusion: In contrast to HLA-DSA, ABO incompatibility or anti-A/B antibody titer was not associated with the development of MVI in allograft tissue.

CITATION INFORMATION: Ko E., Choi B., Park C., Kim Y., Yang C., Chung B. Comparison of Microvascular Inflammation in Renal Allograft Tissue between ABO Incompatible and ABO Compatible Kidney Transplantation Am J Transplant. 2017;17 (suppl 3).

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To cite this abstract in AMA style:

Ko E, Choi B, Park C, Kim Y, Yang C, Chung B. Comparison of Microvascular Inflammation in Renal Allograft Tissue between ABO Incompatible and ABO Compatible Kidney Transplantation [abstract]. https://atcmeetingabstracts.com/abstract/comparison-of-microvascular-inflammation-in-renal-allograft-tissue-between-abo-incompatible-and-abo-compatible-kidney-transplantation/. Accessed June 6, 2025.

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