Comparison of Intraoperative Cortical Renal Blood Flow after Reperfusion Using Laser Speckle Flowgraphy Device between Adult and Pediatric Kidney Transplants
Nephrology, Toho University Faculty of Medicine, Tokyo, Japan
Meeting: 2020 American Transplant Congress
Abstract number: C-046
Keywords: Kidney, Laser Doppler flowmetry, Microcirculation, Monitoring
Session Information
Session Name: Poster Session C: Kidney: Pediatrics
Session Type: Poster Session
Date: Saturday, May 30, 2020
Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
Location: Virtual
*Purpose: Laser speckle flowgraphy (LSFG) is a device to monitor cutaneous and ocular fundus blood flow. The aim of this study reveals that the differences of cortical renal blood flow after reperfusion using LSFG between adult and pediatric kidney transplants.
*Methods: We analyzed 102 patients who received a live-related donor renal transplant at our center between October 2015 and December 2018. The patients were divided into two groups: adults (n=68, over 20 y/o, group A) and children (n=34, group B). The cortical microcirculation at the anterior surface of graft was measured at 5, 10 and 60 min after reperfusion using LSFG which was placed 45cm above a graft. Mean blur rate (MBR) (arbitrary unit, a.u.) and beat strength (BS: maximum MBR-minimum MBR) (a.u.) were available for evaluated values of the blood flow (Fig).
*Results: Recipient age was 49.2±13.9 y/o in group A and 7.6±4.9 y/o in group B, and donor age was 58.7±10.6 y/o in group A and 40.8±10.8 y/o in group B. Recipient weight (R-wt) and donor weight (D-wt) (kg) significantly differed between both groups (R-wt and D-wt; 61.3±14.0 and 57.7±9.1 in group A, 19.7±12.7 and 62.6±0.5 in group B, p<0.05 in both groups). The ration of R-wt / D-wt in group A was higher than that in group B (1.1±0.3 vs 0.3±0.2, p<0.001).There were no differences of warm and cold ischemic time in both groups (WIT: group A 3.5±1.3min and group B 3.5±1.0min, CIT: group A 92.4±32.7min and group B 93.1±33.3min). MBR had increased over time in both groups. In group A, MBR was numerically higher than those in group B (5, 10 and 60 min: 496.7±131.2, 542.3±110.4, 590.1±100.9 in group A and 484.2±118.8, 529.9±128.2, 573.8±107.8 in group B). On the contrary, BS had attenuated over time and there were statistical significant differences between both groups (5, 10 and 60 min: 148.0±73.8, 125.1±65.2, 93.0±37.0 in group A and 99.6±40.6, 86.1±39.6, 68.0±29.6 in group B, p<0.01 in all periods). Initial urine output time was 15 min (IQR 10-35.5) in group A and 18 min (IQR 13-45) in group B (p=0.184).
*Conclusions: Increased the blood flow and reduced fluctuation of the blood flow after reperfusion were observed in adult and pediatric transplants. Size-mismatch between pediatric recipients and adult kidneys created large vascular beds and it may contribute to lower fluctuation of blood flow in pediatric transplants.
To cite this abstract in AMA style:
Muramatsu M, Sakurabayashi K, Itabashi Y, Takahashi Y, Mizutani T, Nishikawa K, Yonekura T, Oguchi H, Shinoda K, Hamasaki Y, Kawamura T, Sakai K, Shishido S. Comparison of Intraoperative Cortical Renal Blood Flow after Reperfusion Using Laser Speckle Flowgraphy Device between Adult and Pediatric Kidney Transplants [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/comparison-of-intraoperative-cortical-renal-blood-flow-after-reperfusion-using-laser-speckle-flowgraphy-device-between-adult-and-pediatric-kidney-transplants/. Accessed May 10, 2025.« Back to 2020 American Transplant Congress