ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Clinical Utility and Interpretation of CKD Stages in Living Kidney Donors

A. Massie,1 M. Henderson,1 F. Al Ammary,1 J. Snyder,2 D. Segev.1

1Johns Hopkins, Baltimore
2SRTR, Minneapolis.

Meeting: 2018 American Transplant Congress

Abstract number: B158

Keywords: Donation

Session Information

Date: Sunday, June 3, 2018

Session Name: Poster Session B: Kidney Living Donor: Long Term Outcomes

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall 4EF

Related Abstracts
  • Clinical Outcomes of Living Kidney Donors With Medullary Sponge Kidney
  • Obesity Is Associated with Increased Risk of ESRD Among Living Kidney Donors.

Current definitions of chronic kidney disease (CKD) staging define any individual with eGFR<60 as having stage 3 or higher CKD. Nearly half of living kidney donors (LKDs) have post-donation eGFR below this threshold, but the clinical interpretation of eGFR<60 in donors is unknown, and the "CKD" label may not be appropriate. Evidence of risk associated with decreased post-donation eGFR is needed to inform international guidelines and best practices for donor followup and care management.

METHODS: Using SRTR data, we studied end-stage renal disease (ESRD) risk in 67,571 LKDs 1999-2015 with at least one reported postdonation serum creatinine (SCr). eGFR was calculated via the CKD-EPI equation. Measurements with eGFR<15 were excluded from analysis. We modeled the association between eGFR category (≥60, 45-59, 30-44, 15-30, corresponding to no CKD, CKD stage 3, stage 4A, and stage 4B) using Cox regression with eGFR category as a time-varying exposure and adjusting for donor age, sex, race (black vs nonblack), BMI, and 1st-degree biological relationship to recipient.

RESULTS: 117,051 CKD measurements were reported at median (IQR) 11 (4-14) months post-donation (90th percentile 25m post-donation). Of these, 33.9% were in the range 45-59, 5.7% were in the range 30-45, and 0.8% were in the range 15-29. In an unadjusted model, eGFR 30-45 was associated with 3.9-fold higher risk of ESRD compared to donors with eGFR≥60 (HR=1.80 3.94 8.60, p<0.01) and eGFR 15-29 was associated with 40-fold higher risk (HR=5.41 40.29 299.77, p<0.001) (Table). After adjustment, these associations persisted with 5.3-fold higher risk for eGFR 30-45 and 54-fold higher risk for eGFR 15-29 (both p<0.001, Table). Donors with eGFR 45-60 had elevated risk but the association was not statistically significant (unadjusted HR=0.81 1.50 2.79, p=0.2; aHR=0.92 1.86 3.77, p=0.08).

CONCLUSIONS: The categorization of eGFR 45-60 as "CKD stage 3" may not be clinically meaningful among LKDs. Nevertheless, eGFR category is associated with ESRD risk among donors with eGFR<30, and our results support current guidelines recommending longitudinal followup of renal function in living kidney donors.

CITATION INFORMATION: Massie A., Henderson M., Al Ammary F., Snyder J., Segev D. Clinical Utility and Interpretation of CKD Stages in Living Kidney Donors Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Massie A, Henderson M, Ammary FAl, Snyder J, Segev D. Clinical Utility and Interpretation of CKD Stages in Living Kidney Donors [abstract]. https://atcmeetingabstracts.com/abstract/clinical-utility-and-interpretation-of-ckd-stages-in-living-kidney-donors/. Accessed January 26, 2021.

« Back to 2018 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.