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Clinical Significance of Late Antibody-Mediated Rejection without Donor Specific Anti-hLA Antibodies

J. Lee1, E. Kim1, S. Yang1, S. Kim1, B. Lim2, H. Choi3, B. Kim4, B. Kim4, M. Ju5, M. Kim1, S. Kim1, Y. Kim1, K. Huh1

1Department of Transplantation Surgery, Severance Hospital, Seoul, Korea, Republic of, 2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Department of Internal Medicine, Gangnam Severance Hospital, Seoul, Korea, Republic of, 4Department of Internal Medicine, Severance Hospital, Seoul, Korea, Republic of, 5Department of Surgery, Gangnam Severance Hospital, Seoul, Korea, Republic of

Meeting: 2020 American Transplant Congress

Abstract number: B-067

Keywords: Alloantibodies, Graft survival, Kidney transplantation, Rejection

Session Information

Session Name: Poster Session B: Kidney Chronic Antibody Mediated Rejection

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: Late onset antibody-mediated rejection (AMR) is a leading cause of kidney allograft failure. Its diagnosis has been based on a combination of morphologic, immunohistologic findings, and presence of donor-specific anti-HLA antibodies (DSA). Although the presence of DSA is no longer required for AMR diagnosis according to Banff 2017 classification, the clinical significance of late onset AMR without DSA remains unclear. Here we compared clinical outcomes of late onset AMR with and without DSA.

*Methods: We analyzed 126 cases of late AMR (> 6 months after transplant) that meet the Banff 2017 histologic criteria for AMR. All cases were diagnosed by for cause biopsy and grouped into DSA-positive (n=103) and DSA-negative (n=23) AMR groups. The estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation.

*Results: The histological picture did not differ between DSA-negative and DSA-positive AMR, with the exception of increased level of peritubular capillaritis in DSA-positive AMR. Median time from transplant to AMR diagnosis was 80 months (IQR, 39-118). At the time of AMR diagnosis, both groups had similar graft function (36.3 ± 16.0 for DSA-negative and 39.7 ± 20.2mL/min/1.73 m2 for DSA-positive AMR, P=0.408). Mean eGFR after AMR were similar irrespective of the presence of DSA. There were 28 (26.2%) graft failures in the DSA-negative and 8 (27.6%) graft failures in the DSA-positive AMR groups, which was not statistically different (P=0.981).

*Conclusions: In late onset AMR, there was no significant difference between AMR with and without DSA in clinical outcomes.

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To cite this abstract in AMA style:

Lee J, Kim E, Yang S, Kim S, Lim B, Choi H, Kim B, Kim B, Ju M, Kim M, Kim S, Kim Y, Huh K. Clinical Significance of Late Antibody-Mediated Rejection without Donor Specific Anti-hLA Antibodies [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/clinical-significance-of-late-antibody-mediated-rejection-without-donor-specific-anti-hla-antibodies/. Accessed June 1, 2025.

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