Clinical Risk Factors for Bronchiolitis Obliterans Syndrome (BOS) in Lung Transplant Recipients (LTRs): Results of an International Cohort Study.

N. Law,¹ B. Hamandi,¹ C. Fegbeutel,² F. Silveira,³ E. Verschuuren,⁴ P. Ussetti,⁵ P. Chin-Hong,⁶ A. Solé,⁷ C.-L. Holmes-Liew,⁸ E. Billaud,⁹ P. Grossi,¹⁰ O. Manuel,¹¹ D. Levine,¹² R. Barbers,¹³ D. Hadjiliadis,¹⁴ L. Singer,¹ S. Husain.¹

¹University Health Network, Toronto, ON, Canada
²Hannover Medical School, Hannover, Germany
³University of Pittsburgh, Pittsburgh, PA
⁴University Medical Center Groningen, University of Groningen, Groningen, Netherlands
⁵Hospital Puerta de Hierro, Madrid, Spain
⁶University of California, San Francisco, CA
⁷University and Polytechnic Hospital La Fe, Universidad de Valencia, Valencia, Spain
⁸Royal Adelaide Hospital, Adelaide, Australia
⁹APHP Hopital Européen G Pompidou, Paris, France
¹⁰University of Insubria, Varese, Italy
¹¹University Hospital of Lausanne, Lausanne, Switzerland
¹²University of Texas Health Science Center San Antonio, San Antonio, TX
¹³KECK Medical Center of University of Southern California, Los Angeles, CA
¹⁴University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, PA

Meeting: 2017 American Transplant Congress

Abstract number: 231

Keywords: Fungal infection, Multicenter studies

Session Information

Session Name: Concurrent Session: Infectious Complications of Transplant

Session Type: Concurrent Session

Date: Monday, May 1, 2017

Session Time: 2:30pm-4:00pm

Presentation Time: 3:30pm-3:42pm

Location: E265

Introduction:

Bronchiolitis obliterates syndrome (BOS) is a major impediment in the long term survival of LTRs. The main objective of this study was to identify infectious risk factors for the development of BOS in a large cohort.

Methods:

We conducted an international, multicenter, retrospective cohort study of 900 consecutive adult lung transplant recipients (LTRs) transplanted between 2005 and 2008, with 4 years follow- up. Multivariable competing risk factors regression analysis was performed to identify risk factors for occurrence of BOS. BOS was defined as per ISHLT criteria of 2001.

Results:

269 patients developed BOS at 4 years post-transplantation (113.3 per 1000-person years). Table 1 presents the univariate and multivariate results of risk factors analysis. None of the infectious related risk factors were substantiated in the multivariate model.Conclusion:

Our study showed that age and immunosuppression related factors were primarily responsible for the development of BOS.

CITATION INFORMATION: Law N, Hamandi B, Fegbeutel C, Silveira F, Verschuuren E, Ussetti P, Chin-Hong P, Solé A, Holmes-Liew C.-L, Billaud E, Grossi P, Manuel O, Levine D, Barbers R, Hadjiliadis D, Singer L, Husain S. Clinical Risk Factors for Bronchiolitis Obliterans Syndrome (BOS) in Lung Transplant Recipients (LTRs): Results of an International Cohort Study. Am J Transplant. 2017;17 (suppl 3).

To cite this abstract in AMA style:

Law N, Hamandi B, Fegbeutel C, Silveira F, Verschuuren E, Ussetti P, Chin-Hong P, Solé A, Holmes-Liew C-L, Billaud E, Grossi P, Manuel O, Levine D, Barbers R, Hadjiliadis D, Singer L, Husain S. Clinical Risk Factors for Bronchiolitis Obliterans Syndrome (BOS) in Lung Transplant Recipients (LTRs): Results of an International Cohort Study. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/clinical-risk-factors-for-bronchiolitis-obliterans-syndrome-bos-in-lung-transplant-recipients-ltrs-results-of-an-international-cohort-study/. Accessed May 12, 2025.

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