Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Due to the limitation of the survival of kidney allograft, increasing number of patients need to take re-transplantation (re-KT) after the first allograft failure. In this study, we investigated the clinical characteristics and clinical outcomes of re-KT recipients in comparison with those of first KT using nationwide registry. We retrospectively analyzed 4757 adult kidney transplant recipients registered in Korean organ transplantation registry database from 2009 to 2012. These cases were divided into 4 groups; first KT (n=2762) and re-KT (n=162) from living donor (LD), first KT (n=1647) and re-KT (n=186) from deceased donor (DD). We compared the clinical outcomes such as early or late biopsy-proven acute rejection and also allograft or patient survival rate across those groups. Out of total 4,757 kidney transplant recipients, 348 (7.5%) cases were re-KT. The proportion of DDKT and sensitized patients was significantly higher in re-KT group compared to first KT group (DDKT; 53.4% versus 37.4%; P<0.05, sensitized patients; 21.6% versus 3.7%, P<0.05). Especially in LDKT, the proportion of ABO incompatible KT was higher in re-KT group than first KT group as well (18.5 % versus 12.5%; P<0.05). The incidence of early biopsy-proven acute rejection (BPAR) was significantly higher in re-KT group than first KT group in DDKT (19.4% versus 11.3%; P<0.05), but not in LDKT (7.4% versus 9.0%; P>.05). Incidence of late BPAR was not significantly different between re-KT and first KT groups both in DDKT (0.6% versus 2.4%; P>.05) and LDKT (1.6% versus 2.6%; P>.05). In multivariate analysis, re-KT was an independent risk factor for development of early BPAR in DDKT (odd ratio, 1.724; 95% confidence interval, 1.10 to 2.67; P<.05). However, allograft and patient survival rate were not significantly different between re-KT and first KT group in DDKT and LDKT (P>.05, for all). Our study showed that overall clinical outcomes of re-KT was comparable to those of first KT, but risk for early BPAR can increase especially when re-KT was performed from DDs.
CITATION INFORMATION: Kim J, Ban T, Jung B, Choi B, Park C, Yang C, Kim Y.-S. Clinical Outcome on Kidney Retransplantation in Comparison with First Kidney Transplantation in Korea – Nationwide Cohort Study. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Kim J, Ban T, Jung B, Choi B, Park C, Yang C, Kim Y-S. Clinical Outcome on Kidney Retransplantation in Comparison with First Kidney Transplantation in Korea – Nationwide Cohort Study. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/clinical-outcome-on-kidney-retransplantation-in-comparison-with-first-kidney-transplantation-in-korea-nationwide-cohort-study/. Accessed March 31, 2020.
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