Background: Donor kidney can have Interstitial fibrosis (IF) and tubular atrophy (TA), and it could be a source of poor graft function after transplantation. However, kidney biopsy of donor can be a dangerous procedure. Thus, this study was prospectively designed to evaluate correlation between the value of acoustic radiation force impulse (ARFI) and IFTA score of donor kidney, and validation of ARFI quantification to predict graft function after transplantation. Methods: Fifty seven adult living renal transplantation donors between June 2010 and October 2012 in our center were enrolled. Before transplantation, all donors were evaluated by ARFI-quantification to measure shear wave velocity (SWV, m/s) in graft kidney. Time-zero biopsies were performed in all graft kidneys before implantation. IFTA score was defined as interstitial fibrosis (CI) + Tubular atrophy (CT) score in Banff 07criteria. Results: Of the 57 donors, 7 donors (12.3%) presented IFTA score 1. The mean value of SWV was 2.23 ± 0.55 m/s. The values of SWV was significantly associated with IFTA score (2.29 ± 0.55, 1.83 ± 0.41 in IFTA score 0, 1, respectively, p=0.04, Table 1). The clinical parameters of donor except to cholesterol level did not showed difference from IFTA score. The IFTA score have significantly association with cholesterol level of donors (p=0.03). Conclusion: These preliminary data showed that values of SWV were significantly associated with IFTA score. Thus, ARFI can be considered as a useful noninvasive method to predict pathologic abnormality of the donor kidney.
To cite this abstract in AMA style:Lee A, Joo D, Oh Y, Jeong H, Lee S, Kim B, Huh K, Kim M, Kim Y, Park K. Clinical Application of Acoustic Radiation Force Impulse in Donor Kidney Compared with Biopsy Results: A Preliminary Report [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/clinical-application-of-acoustic-radiation-force-impulse-in-donor-kidney-compared-with-biopsy-results-a-preliminary-report/. Accessed November 13, 2019.
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