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Clinical and Demographic Factors Affecting Patient and Graft Survival in Pancreas Transplant Recipients: The Efispan Study

P. Ventura-Aguiar1, M. Cabello2, I. Beneyto3, D. Navarro Cabello4, G. Tabernero5, A. Alonso6, J. Ruiz7, S. Llorente8

1Nephrology and Kidney Transplantation, Hospital Clinic Barcelona, Barcelona, Spain, 2Department of Nephrology, Hospital Carlos Haya, Malaga, Spain, 3Department of Nephrology, Hospital La Fe, Valencia, Spain, 4Department of Nephrology, Hospital Reina Sofía, Cordoba, Spain, 5Department of Nephrology, Hospital Universitario de Salamanca, Salamanca, Spain, 6Department of Nephrology, Hospital Universitario de A Coruña, A Coruña, Spain, 7Department of Nephrology, Hospital Marqués de Valdecilla, Santander, Spain, 8Department of Nephrology, Hospital Virgen de la Arrixaca, Murcia, Spain

Meeting: 2020 American Transplant Congress

Abstract number: B-304

Keywords: Pancreas, Pancreas transplantation

Session Information

Session Name: Poster Session B: Pancreas and Islet: All Topics

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: Pancreas transplantation is an established treatment for diabetic patients with end-stage renal disease. Graft outcomes have improved in the last decades, but data regarding patient and graft outcomes is mainly derived from registries or prospective single centre studies.

*Methods: We conducted a retrospective, longitudinal, multicentre study to assess risk factors that impact on patient and graft survival in pancreas transplant recipients between January 2008 and December 2012 in 8 centres in Spain. Both simultaneous pancreas-kidney (SPK), pancreas-after-kidney (PAK), and pancreas transplant alone (PTA) were included. Data were collected from until 31 December 2015.

*Results: A total of 301 patients were included during the study period. The majority had diabetes mellitus type I (96.7%) for a mean (±standard deviation) time until transplantation of 26.1 years (±7.48). A total of 282 patients (93.7%) survived from transplantation until the end of study, and 19 patients died owing mostly to infections (n=10). Among 55 patients (18.3%) with pancreas graft loss, the main reasons were vascular thrombosis (n=19), chronic rejection (n=10), acute rejection (n=6), and death with a functioning graft (n=5). There were no clear risk factors identified for patient survival, and the rate of cardiovascular-related deaths was 6.3% at 5 years post-transplant. Graft survival was superior in SPK recipients when compared to pancreas alone (either PAK or PTA). Glycaemia, serum creatinine, and control of traditional cardiovascular risk factors was optimal at follow-up.

*Conclusions: This multicenter study highlight the excellent patient and pancreas graft outcomes in pancreas transplantation, with a notably low incidence of cardiovascular events

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To cite this abstract in AMA style:

Ventura-Aguiar P, Cabello M, Beneyto I, Cabello DNavarro, Tabernero G, Alonso A, Ruiz J, Llorente S. Clinical and Demographic Factors Affecting Patient and Graft Survival in Pancreas Transplant Recipients: The Efispan Study [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/clinical-and-demographic-factors-affecting-patient-and-graft-survival-in-pancreas-transplant-recipients-the-efispan-study/. Accessed May 11, 2025.

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