BK virus (BKV) nephropathy has emerged as a significant cause of graft dysfuction in kidney allograft recipients after using powerful immunosupressive treatment protocols in recent years. In this study, we aimed to investigate the incidence, causes and clinical results of BKV infection in 107 renal transplant patients (65 living-related, 42 cadaveric).

We performed BK virus PCR assay screening for the presence of viremia in all patients. In addition, patients with renal dysfunction were evaluated by graft biopsy for detection of BKV nephropathy (BKVN). Subsequently, we compared in patients with significant viremia and/or BKVN (Group I) and without these findings (Group II) in terms of biochemical parameters and clinical findings.

BK virus aasociated disease was totally detected in 14 patients (12 viremia/6 BKVN). Serum creatinine levels were found to be statistically significantly higher in 6 patients of biopsy proven BKVN. According to other biochemical parameters, the statistically significant differences between two groups were not found. Additionally, it was detected that older age and tacrolimus usage are important risk factors for developing BKVN. Demographic characteristics and important features associated BKVN are presented

In immunocompromised renal transplant receviers, BKV is associated with tubulointersititial nephritis and ureteral stenosis. Risk factors associated with BKV infection are old age, male gender, caucasians, ureteral trauma, diabetes mellitus, delayed graft function, CMV and the treatment of acute rejection. In our study among risk factors, old age and tacrolimus usage were detected significantly higher. BKVN is an important cause of graft loss. So, screening test should be done regularly. In patients with significantly raised viral copy number, immunosupressive treatment protocol must be revised.

« Back to 2015 American Transplant Congress