Date: Sunday, June 12, 2016
Session Name: Poster Session B: Kidney: Cardiovascular and Metabolic
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Background: Klotho, a co-receptor for FGF23, is predominantly expressed in kidney and reported to have anti-oxidant and anti-fibrotic properties. Soluble-Klotho (sKl), the cleaved circulating protein, declines dramatically with kidney disease and is inversely associated with mortality. Aim: To evaluate change in sKl over 12 months following kidney transplantation. Methods: Incident kidney transplant recipients (KTRs) were recruited with blood sampled at 4 time-points; pre-transplantation (baseline), 1-week, 12-weeks and 52-weeks post transplantation. Samples were assayed for basic biochemistry and sKl (IBL, Japan). Within-subject comparisons were evaluated using repeat-measure ANOVA/Friedman's test. Results: Samples from 29 KTRs were available for final analysis. Median KTR age was 49 (35-55) years. Seventeen (59%) were male, 26(90%) were living kidney allografts and 10 (34%) were pre-emptive. Table 1 summarises the change across the relevant measured parameters. Compared with baseline, sKl exhibited an increase at 52w following initial decline at 1w (p<0.005 and p<0.01 respectively). Conclusions: This prospective study demonstrated modest sKl increase post kidney transplantation despite excellent graft function achieved, suggesting factors beyond renal capacity influencing circulating sKl. Longer-term evaluation and investigation specifically addressing effects of immunosuppression on sKl are required.
|sKlotho, pg/mL||307 (279-460)||273 (246-343)b||352 (286-417)c||460 (311-525)a,c|
|Serum phosphate (sPi), mmol/L||1.78 ± 0.5||0.81 ± 0.29a||0.88 ± 0.19a||0.92 ± 0.17a|
|Serum creatinine (sCr), umol/L||638 (537-722)||113 (92-142)a||112 (99-130)a||111 (97-131)a|
|eGFR,ml/min/1.73m2||7.4 (6.5-8.7)||63.2 (46.5-87.4)a||61.2 (51.7-71.9)a||60.4 (50.5-71.6)a|
Data presented as Median (IQR) or Mean ± SD. Friedman test or repeat measures ANOVA performed. a p<0.005 c/w baseline. b p≤0.01 c/w baseline. cp<0.005 c/w 7-day.
CITATION INFORMATION: Tan S.-J, Crosthwaite A, Langsford D, Obeysekere V, Ierino F, Roberts M, Holt S, Hewitson T, Dwyer K, Toussaint N. Circulating Soluble-Klotho Levels Modestly Increase After Renal Transplantation. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Tan S-J, Crosthwaite A, Langsford D, Obeysekere V, Ierino F, Roberts M, Holt S, Hewitson T, Dwyer K, Toussaint N. Circulating Soluble-Klotho Levels Modestly Increase After Renal Transplantation. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/circulating-soluble-klotho-levels-modestly-increase-after-renal-transplantation/. Accessed February 23, 2019.
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