ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Change in Estimated Glomerular Filtration Rate Pre and Post Development of Donor-Specific Antibodies after Kidney Transplantation

B. Ho,1 S. Montag,1,2 H. Bhagat,3 K. Atiemo,1 A. Daud,1 R. Kang,1 L. Zhao,1,2 J. Schwartz,3 D. Ladner.1

1Northwestern University Transplant and Outcomes Research Collaborative (NUTORC), Chicago
2Dept of Preventive Medicine, Northwestern University, Chicago
3Astellas Pharma Global Development, Inc., Northbrook.

Meeting: 2018 American Transplant Congress

Abstract number: D84

Keywords: Glomerular filtration rate (GFR), HLA antibodies, Kidney transplantation, Renal function

Session Information

Session Name: Poster Session D: Kidney Complications: Late Graft Failure

Session Type: Poster Session

Date: Tuesday, June 5, 2018

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall 4EF

Formation of de novo donor-specific antibodies (dnDSA) against human leukocyte antigens contributes to inferior kidney transplant (KT) outcomes. We assessed the effect of dnDSA on estimated glomerular filtration rate (eGFR) in the largest single-center KT cohort to date.

Demographic, graft, and patient data were collected for all adult KT recipients (KTRs) in the Northwestern Medicine transplant center (2007–2015). DSA was assessed at KT (time 0), 3 and 6 months, 1 and 2 years, and for cause. Patient groups were: never had DSA, dnDSA, and DSA at KT. Kidney allograft function was assessed by eGFR from 1 month post KT using the Modification of Diet in Renal Disease 4 equation with calculation of the annual mean rate of eGFR change. eGFR over time was examined via linear mixed effect models.

Overall, 1517 KTRs (mean ±standard deviation age 49.5±13.2 yrs, 36.9% female) were followed for ≤8 yrs (mean 4.4 yrs). Patient demographics are presented in the Table. Mean estimated annual rate of eGFR change (mL/min/1.73m2) was 0.01 overall and −0.02 for DSA at KT. Mean estimated annual rate of eGFR change (mL/min/1.73m2) was 0.08 vs −0.06 pre- and post-dnDSA development, respectively (class I: 0.08 vs −0.08; class II: 0.03 vs −0.08) (Figure).

Renal function improved post KT, prior to the development of dnDSA, and worsened afterwards, at a rate greater than DSA at KT. Multivariable analysis, however, was not attempted due to the large baseline differences between groups and insufficient sample size to adjust for all covariates. However, minimizing DSA formation may help preserve long-term allograft function in KTRs.

CITATION INFORMATION: Ho B., Montag S., Bhagat H., Atiemo K., Daud A., Kang R., Zhao L., Schwartz J., Ladner D. Change in Estimated Glomerular Filtration Rate Pre and Post Development of Donor-Specific Antibodies after Kidney Transplantation Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Ho B, Montag S, Bhagat H, Atiemo K, Daud A, Kang R, Zhao L, Schwartz J, Ladner D. Change in Estimated Glomerular Filtration Rate Pre and Post Development of Donor-Specific Antibodies after Kidney Transplantation [abstract]. https://atcmeetingabstracts.com/abstract/change-in-estimated-glomerular-filtration-rate-pre-and-post-development-of-donor-specific-antibodies-after-kidney-transplantation/. Accessed June 2, 2025.

« Back to 2018 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences