C-C Chemokine Receptor 5 Polymorphisms and Risk of Antibody-Mediated Rejection in Renal Transplantation.
1Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea
2Nephrology, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea
Meeting: 2017 American Transplant Congress
Abstract number: B72
Keywords: Antibodies, Gene polymorphism, Kidney transplantation, Rejection
Session Information
Session Name: Poster Session B: Antibody Mediated Rejection in Kidney Transplant Recipients II
Session Type: Poster Session
Date: Sunday, April 30, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Antibody-mediated rejection (AMR) is the leading cause of graft failure after kidney transplantation. C-C Chemokine receptor 5 (CCR5) plays an important role in immune cell migration and cytokine release. The CCR5 deficient mice have been implicated in experimental model for AMR. The aim of this study is to investigate the influence of genetic variation of CCR5 in susceptibility to AMR after kidney transplantation
We analyzed 190 recipients who underwent kidney transplantation without pre-transplant donor specific antibodies between May 2013 and December 2014. We investigated a CCR5 promoter polymorphism, -2459 A>G (rs1799987), that has been shown to affect expression of the CCR5 receptor. Genetic polymorphism was detected by the TaqMan assay.
AMR occurred in 20 patients (10.5%) of 190 kidney transplant recipients within 1 year. The incidences of AMR for AA genotype, AG genotype, and GG genotype were 25% (11/44), 7.1% (7/98), and 4.2% (2/48), respectively (p=0.001). The recipient AA genotype of CCR5 -2459 A>G (rs1799987) was associated with increased risk for AMR after adjusting for covariates such as ABO incompatibility, human leukocyte antigen mismatch, and panel reactive antibodies (OR, 7.123; 95% CI, 1.411-35.967; p=0.017).
The CCR5 -2459 (rs1799987) AA genotype of recipient was an independent risk factor for AMR after kidney transplantation.
CITATION INFORMATION: Lee J, Kim D, Lee J, Kwon S.-K, Song S, Lee J, Kim B, Kim M, Kim S, Kim Y, Huh K. C-C Chemokine Receptor 5 Polymorphisms and Risk of Antibody-Mediated Rejection in Renal Transplantation. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Lee J, Kim D, Lee J, Kwon S-K, Song S, Lee J, Kim B, Kim M, Kim S, Kim Y, Huh K. C-C Chemokine Receptor 5 Polymorphisms and Risk of Antibody-Mediated Rejection in Renal Transplantation. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/c-c-chemokine-receptor-5-polymorphisms-and-risk-of-antibody-mediated-rejection-in-renal-transplantation/. Accessed June 3, 2025.« Back to 2017 American Transplant Congress