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Associations of Perfusate Biomarkers and Pump Parameters with Delayed Graft Function and Deceased-Donor Kidney Allograft Function.

C. Parikh,1 I. Hall,1 R. Bhangoo,2 J. Ficek,1 P. Abt,3 H. Thiessen-Philbrook,1 H. Lin,1 M. Bimali,1 P. Murray,4 V. Rao,1 B. Schröppel,5 M. Doshi,6 F. Weng,7 P. Reese.3

1Yale University School of Medicine, New Haven, CT
2University of Arizona College of Medicine, Phoenix, AZ
3University of Pennsylvania, Philadelphia, PA
4University College Dublin, Dublin, Ireland
5Mount Sinai School of Medicine, New York, NY
6Wayne State University, Detroit, MI
7Barnabas Health, Livingston, NJ.

Meeting: 2016 American Transplant Congress

Abstract number: C187

Keywords: Glomerular filtration rate (GFR), Kidney transplantation, Pulsatile preservation

Session Information

Date: Monday, June 13, 2016

Session Name: Poster Session C: Kidney Transplantation: AKI/Preservation/DCD

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Related Abstracts
  • Correlation Between Level of Biomarkers Measured in Perfusate of Machine-Preserved ECD/DCD Kidneys and Post-Transplant Graft Function
  • Associations Between Deceased-Donor Urine Biomarkers of Kidney Injury and 6-Month Kidney Transplant Function

Hypothermic machine perfusion (HMP) is increasingly used in deceased-donor kidney transplantation, but controversy exists regarding the value of perfusion biomarkers and pump parameters for assessing organ quality. We prospectively determined associations between perfusate biomarkers [neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18) and liver-type fatty acid-binding protein (L-FABP)] and pump parameters (resistance and flow) with outcomes of delayed graft function (DGF) and 6-month estimated glomerular filtration rate (eGFR). DGF occurred in 230/671 (34%) recipients. Only 1-hour flow was inversely associated with DGF. Higher NGAL or L-FABP concentrations and increased resistance were inversely associated with 6-month eGFR, while higher flow was associated with higher adjusted 6-month eGFR. Discarded kidneys had consistently higher median resistance and lower median flow than transplanted kidneys, but median perfusate biomarker concentrations were either lower or not significantly different in discarded compared with transplanted kidneys. Notably, most recipients of transplanted kidneys with isolated “undesirable” biomarker levels or HMP parameters experienced acceptable 6-month allograft function, suggesting these characteristics should not be used in isolation for discard decisions. Additional studies must confirm the utility of combining HMP measurements with other characteristics to assess kidney quality.

CITATION INFORMATION: Parikh C, Hall I, Bhangoo R, Ficek J, Abt P, Thiessen-Philbrook H, Lin H, Bimali M, Murray P, Rao V, Schröppel B, Doshi M, Weng F, Reese P. Associations of Perfusate Biomarkers and Pump Parameters with Delayed Graft Function and Deceased-Donor Kidney Allograft Function. Am J Transplant. 2016;16 (suppl 3).

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To cite this abstract in AMA style:

Parikh C, Hall I, Bhangoo R, Ficek J, Abt P, Thiessen-Philbrook H, Lin H, Bimali M, Murray P, Rao V, Schröppel B, Doshi M, Weng F, Reese P. Associations of Perfusate Biomarkers and Pump Parameters with Delayed Graft Function and Deceased-Donor Kidney Allograft Function. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/associations-of-perfusate-biomarkers-and-pump-parameters-with-delayed-graft-function-and-deceased-donor-kidney-allograft-function/. Accessed March 8, 2021.

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