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Association of Native Kidney Disease with De Novo Cancer Development After Kidney Transplant

Y. Caliskan1, D. Axelrod2, R. Li1, W. Cheungpasitporn3, M. Schnitzler1, M. McAdams DeMarco4, J. Ahn4, T. Alhamad5, H. Randall1, S. Bae4, D. Segev4, K. L. Lentine1

1Saint Louis University, Saint Louis, MO, 2University of Iowa, Iowa City, IA, 3Mayo Clinic, Rochester, MN, 4John Hopkins University, Baltimore, MD, 5Washington University in Saint Louis, Saint Louis, MO

Meeting: 2022 American Transplant Congress

Abstract number: 66

Keywords: Kidney transplantation, Malignancy, Nephritis, Renal failure

Topic: Clinical Science » Organ Inclusive » 67 - Non-PTLD/Malignancies

Session Information

Session Name: PTLD and Malignancies

Session Type: Rapid Fire Oral Abstract

Date: Sunday, June 5, 2022

Session Time: 3:30pm-5:00pm

 Presentation Time: 4:40pm-4:50pm

Location: Hynes Room 309

*Purpose: Primary glomerulonephritis (GN) and congenital anomalies of the kidney and urinary tract (CAKUT) have been shown to be associated with cancer development in the general population. However, the association between the etiology of kidney failure and de novo cancers after kidney transplant (KTx) needed to be clarified.

*Methods: We examined national Scientific Registry of Transplant Recipients (SRTR) data for adult patients who underwent KTx (2000-2020) to investigate the association of native kidney disease with de novo cancer diagnoses 6 months to 5 years after KTx. Patients with a history of transplant and cancer before KTx were excluded. We identified KTx recipients with hypertension (HTN) (n=68432), diabetes mellitus (DM) (n=79809), glomerulonephritis (GN) (n=54381), CAKUT (n=6508) and others (n=56048) as causes of native kidney disease.

*Results: Compared with the reference HTN group, the GN (aHR, 1.311.391.48) and CAKUT (aHR, 1.201.371.57) groups were significantly associated with a higher risk of new-onset cancers at 6 months to 5 years post-KTx (Figure 1). GN (aHR, 1.231.311.39) and CAKUT (aHR, 1.091.241.40) groups are also associated with a higher risk of acute rejection within the 12 months post-KTx. Regarding graft failure, GN (aHR, 0.890.920.95) and other (aHR, 0.770.800.82) groups have a significantly lower risk of 5-years all cause graft failure compared with the reference group (Figure 2). However, the risk of death censored graft failure was significantly lower in DM (aHR, 0.840.900.96) and other (aHR, 0.800.830.87) groups.

*Conclusions: Etiologies of kidney failure, GN and CAKUT, have been associated with acute rejection and de novo cancers after KTx. Immunosuppressive treatment and cancer screening may need to be modified according to the native kidney disease.

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To cite this abstract in AMA style:

Caliskan Y, Axelrod D, Li R, Cheungpasitporn W, Schnitzler M, DeMarco MMcAdams, Ahn J, Alhamad T, Randall H, Bae S, Segev D, Lentine KL. Association of Native Kidney Disease with De Novo Cancer Development After Kidney Transplant [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/association-of-native-kidney-disease-with-de-novo-cancer-development-after-kidney-transplant/. Accessed May 28, 2025.

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