Association between Genetic Polymorphisms of Fc Gamma Receptor Genes (FcgR) and the Development of Donor Specific Antibodies (DSA) after Kidney Transplant
1College of Pharmacy, Western University of Health Sciences, Pomona, CA
2National Institute of Transplantation Foundation, Los Angeles, CA
3Multi-Organ Transplant Center, St. Vincent Medical Center, Los Angeles, CA.
Meeting: 2018 American Transplant Congress
Abstract number: D87
Keywords: Alloantibodies, Gene polymorphism, Kidney/liver transplantation
Session Information
Session Name: Poster Session D: Kidney Complications: Late Graft Failure
Session Type: Poster Session
Date: Tuesday, June 5, 2018
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
Background: Antibody mediated rejection (AMR) is one of the most important barriers to improve long-term kidney transplant outcomes. The presence of donor specific antibodies (DSA) in the patients is a major indicator for AMR. DSA is associated with Class 1 or Class 2 antigens. Previous studies have suggested an association between genetic variations in Fc gamma receptors and susceptibility to AMR. This study aims to determine the association between gene polymorphisms of Fc gamma receptor with the development of DSA and subsequent AMR. It is hypothesized that there is an association between gene polymorphisms of Fc gamma receptors and the development of DSA.
Methods: This is a retrospective study. A total of 400 patients who received kidney allograft at the St. Vincent Medical Center between January 2008 and December 2012. Among these, the patients with no genomic data or DSA data were excluded (162 patients). The remaining 238 patients were divided into two groups, the first group was positive for the presence of DSA and the other group was negative of DSA. Furthermore, additional testing was conducted to test the presence of DSA after 1 year and whether those DSA were class 1 or 2. A chi square test was used for comparison and the odd ratios were calculated.
Results: There were four genes of Fc gamma receptors with single nucleotide polymorphisms (SNPs) that were analyzed, which were FcgR2B (rs1050501), FcgR2C (rs10917661), FcgR2A (rs1801271), and FcgR3A (rs396991). Polymerase chain reactions were conducted for each gene. One gene, FcgR3A (rs396991) showed a statistically significant difference between the 2 groups. The presence of C allele (vs. A) increased the detection of DSA by an odds ratio of 2. (CI [1.140-3.520], c2 = 5.9, p = 0.015). No other statistically significant differences were seen with the other genetic polymorphisms of the Fc gamma receptors.
Conclusion: This study suggests that gene polymorphisms of FcgR3A (rs396991) have an association with increased risk of class 2 DSA development, which is associated with higher risk of AMR.
CITATION INFORMATION: Min D., Chang Y., Shah T. Association between Genetic Polymorphisms of Fc Gamma Receptor Genes (FcgR) and the Development of Donor Specific Antibodies (DSA) after Kidney Transplant Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Min D, Chang Y, Shah T. Association between Genetic Polymorphisms of Fc Gamma Receptor Genes (FcgR) and the Development of Donor Specific Antibodies (DSA) after Kidney Transplant [abstract]. https://atcmeetingabstracts.com/abstract/association-between-genetic-polymorphisms-of-fc-gamma-receptor-genes-fcgr-and-the-development-of-donor-specific-antibodies-dsa-after-kidney-transplant/. Accessed May 16, 2025.« Back to 2018 American Transplant Congress