ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Application of Diffusional Kurtosis Imaging for Non-Invasive Assessment of Chronic Allograft Injury

Y. Xu1, X. Zheng2, H. Liu1, X. Hu1

1Department of Urology, Capital Medical University Beijing Chaoyang Hospital, Urology Institute of Capital Medical University, Beijing, China, 2Urology Department, Beijing YouAn Hospital, Capital Medical University, Beijing, China

Meeting: 2020 American Transplant Congress

Abstract number: B-092

Keywords: Graft function, Kidney transplantation, Magnetic resonance imaging

Session Information

Session Name: Poster Session B: Kidney Complications: Non-Immune Mediated Late Graft Failure

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: To evaluate the feasibility and clinical application of diffusional kurtosis imaging (DKI) technique in non-invasive assessment for chronic allograft injury (CAI).

*Methods: The local ethics committee approved this study; written informed consent was obtained. Between January 2018 and October 2019, a total of 105 renal allograft recipients were recruited and divided into allograft function normal(eGFR≥60) and abnormal(eGFR<60) groups for analysis and screening of relevant DKI parameters. Then they were grouped on eGFR (mL/min/1.73m2) levels to 3 groups: group 1, eGFR≥60(n=5); group 2, eGFR 30-60 (n=69); group 3, eGFR<30 (n=31). DKI was performed on a clinical 3 T magnetic resonance imaging (MRI) system, and region-of-interest measurements were conducted to determine mean kurtosis (K), mean diffusivity (D), and apparent diffusion coefficient (ADC) of the kidney cortex and medulla. Renal biopsy specimens were performed in allograft functionabnormal group randomly.

*Results: Mean D values of the renal cortex were significantly lower in the eGFR abnormal group. And Mean D values of the renal cortex decreased gradually with the increase of creatinine, whereas there is a significant difference in the value of D values of cortex between different eGFR groups. (p<0.05). And biopsy result confirmed interstitial fibrosis and tubular atrophy (IFTA).

*Conclusions: As allograft injury progresses, the perfusion of renal might be reduced, and the molecular of the renal cortex might be influenced. The DKI quantitative parameter D of the renal cortex can non-invasively assess CAI to some extent. DKI technique is expected to be an effective, natural, and non-invasive method to detect CAI.

 border=

 border=

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Xu Y, Zheng X, Liu H, Hu X. Application of Diffusional Kurtosis Imaging for Non-Invasive Assessment of Chronic Allograft Injury [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/application-of-diffusional-kurtosis-imaging-for-non-invasive-assessment-of-chronic-allograft-injury/. Accessed May 10, 2025.

« Back to 2020 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences