An Analysis of Non-Tuberculous Mycobacteria (NTM) Infection and Colonization in Lung Transplant Recipients (LTRs) Post-Transplant: A Single Center Matched Cohort Study.
1University of Toronto, Toronto, ON, Canada
2Toronto General Hospital, Toronto, ON, Canada
3University of Alberta, Edmonton, AB, Canada.
Meeting: 2016 American Transplant Congress
Abstract number: B282
Keywords: Infection, Lung infection, Lung transplantation, Outcome
Session Information
Session Name: Poster Session B: Lung Transplantation Posters
Session Type: Poster Session
Date: Sunday, June 12, 2016
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Purpose
NTM is a common infection after Lung transplantation. The role of presence of granuloma in the explanted lungs of LTRs in subsequent development of infection (inf) or colonization (col) post-transplant is not well known.
Methods
We performed matched cohort study of LTRs with granulomas in the explanted lungs (n=148) and matched them with the concurrent LTRs without granuloma (n=148), underlying diagnosis and type of transplant from January 2000 to December 2012. Outcomes assessed included NTM inf or col, and all-cause mortality at 2 years post-transplant.
Results
Within this study period 148 LTRs had granulomas in the explanted lungs, from these 49% (73/148) had non-necrotizing granulomas and 51% (75/148) had necrotizing granulomas. Pre-transplant NTM col and inf was present in 31 and 15 of LTRs respectively. LTRs with necrotizing granuloma were significantly more likely to have NTM col and inf pre-transplant. The distribution of NTM col and inf is shown below (Figure).
In multivariate analysis presence of necrotizing granuloma in the explanted lung, AFB positivity of the granuloma, pre-transplant NTM col or inf and receipt of single lung transplant did not predict the subsequent development of NTM col or inf post-transplant. At 2 years post-transplant, there was no difference in all-cause mortality between LTRs with pre or post-transplant NTM inf or col as compared to those without.
Conclusion
In our cohort the presence of necrotizing granuloma in the explanted lung, AFB positivity of the granuloma or pre-transplant NTM col and inf did not predict the subsequent development of NTM col or inf post-transplant. Pre- or post-transplant NTM col or inf was not associated with increased risk mortality at 2 years after transplantation.
CITATION INFORMATION: Kozlowski H, Kabbani D, Chaparro C, Singer L, Rotstein C, Keshavjee S, Husain S. An Analysis of Non-Tuberculous Mycobacteria (NTM) Infection and Colonization in Lung Transplant Recipients (LTRs) Post-Transplant: A Single Center Matched Cohort Study. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Kozlowski H, Kabbani D, Chaparro C, Singer L, Rotstein C, Keshavjee S, Husain S. An Analysis of Non-Tuberculous Mycobacteria (NTM) Infection and Colonization in Lung Transplant Recipients (LTRs) Post-Transplant: A Single Center Matched Cohort Study. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/an-analysis-of-non-tuberculous-mycobacteria-ntm-infection-and-colonization-in-lung-transplant-recipients-ltrs-post-transplant-a-single-center-matched-cohort-study/. Accessed May 8, 2025.« Back to 2016 American Transplant Congress