ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Alemtuzumab Mitigates the Risk of Early Rejection Associated with Delayed Graft Function in Deceased Donor Renal Transplantation

D. Goodall, M. Willicombe, A. Rizzello, J. Galliford, A. McLean, D. Taube

Imperial College Kidney and Transplant Centre, London, United Kingdom

Meeting: 2013 American Transplant Congress

Abstract number: D1527

Related Abstracts
  • Surgical Anastomosis Time and Its Effect on Delayed Graft Function and Early Outcomes in Deceased Donor Kidney Transplantation
  • Rituximab or Alemtuzumab Induction for ABO Incompatible Renal Transplantation?

Delayed graft function [DGF] is associated with rejection [AR] and allograft loss. It is postulated that ischaemic injury up regulates the expression of allograft MHC leading to an increased risk of rejection.

AR occurs later in patients receiving Alemtuzumab (ALZ) than with other induction agents and the aim of this study was to compare the impact of DGF on the incidence of rejection in recipients of deceased donor kidneys (DDTx) receiving either ALZ or an IL2 receptor antagonist (IL2Ra).

We retrospectively studied 390 patients [m260, f130, mean age was 48.8 ± 13.7 yrs] who received a DDTx at our centre between 2005 and 2011. We excluded all patients with preformed DSAbs detected by luminex. 332(85.1%) and 58(14.9%) patients received ALZ and IL2Ra induction respectively. All patients received tacrolimus based maintenance immunotherapy with corticosteroids for one week only. The mean follow up was 41.9 ± 19.8 months.

118/390 (30.3%) of patients had DGF with no difference between the ALZ and IL2Ra groups, p=0.99.

There was no difference in patient survival at 3 yrs between the groups, being 97.3% and 89.7% in the ALZ group with no DGF and DGF respectively; 91.0% and 94.4% in the IL2Ra group with no DGF and DGF respectively, p=0.1.

Allograft survival was inferior in the patients with DGF irrelevant of induction, censored allograft survival being 91.7%, 82.5% in the ALZ group with no DGF and DGF respectively and 88.6% and 82.6% in the IL2Ra group with no DGF and DGF respectively, p=0.02.

Patients who received an IL2Ra were at highest risk of rejection in the first 3 months post transplant, p=0.03 as shown in figure1.

This difference is subsequently lost and the 3 year rejection free survival is 79.6% in the ALZ with no DGF, 75.1% in the ALZ with DGF, 76.5% in the Il2Ra with no DGF and 70.7% in the IL2Ra group with DGF, p=0.4.

This study shows that ALZ induction mitigates the risk of rejection associated with DGF in the early post-transplant period but that this is not sustained.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Goodall D, Willicombe M, Rizzello A, Galliford J, McLean A, Taube D. Alemtuzumab Mitigates the Risk of Early Rejection Associated with Delayed Graft Function in Deceased Donor Renal Transplantation [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/alemtuzumab-mitigates-the-risk-of-early-rejection-associated-with-delayed-graft-function-in-deceased-donor-renal-transplantation/. Accessed January 22, 2021.

« Back to 2013 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
    • Penis Transplantation: First U.S. Experience.
    • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
    • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
    • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
    • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

    Visit Our Partner Sites

    American Transplant Congress (ATC)

    Visit the official site for the American Transplant Congress »

    American Journal of Transplantation

    The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

    American Society of Transplantation (AST)

    An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

    American Society of Transplant Surgeons (ASTS)

    The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

    Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

    Privacy Policy

    loading Cancel
    Post was not sent - check your email addresses!
    Email check failed, please try again
    Sorry, your blog cannot share posts by email.
    This site uses cookies: Find out more.