ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Adenovirus Enteritis Following Intestinal Transplantation

S. Jafri1, A. Mavis2, J. Weiner3, M. C. Segovia2

1Henry Ford Health System, Detroit, MI, 2Duke University, Durham, NC, 3Columbia, New York, NY

Meeting: 2022 American Transplant Congress

Abstract number: 344

Keywords: Adenoviruses, Infection, Intestinal transplantation, Multivisceral transplantation

Topic: Clinical Science » Small Bowel » 66 - Intestinal Transplantation and Rehabilitation

Session Information

Session Name: Intestinal Transplantation and Rehabilitation

Session Type: Rapid Fire Oral Abstract

Date: Monday, June 6, 2022

Session Time: 5:30pm-7:00pm

 Presentation Time: 5:50pm-6:00pm

Location: Hynes Room 206

*Purpose: Intestinal transplant is a life-saving therapy for intestinal failure. Adenovirus Enteritis (AE) is an unusual infection identified on biopsy or serology following intestine or multivisceral transplantation. AE can complicate patient course following intestine and multivisceral transplantation. Solid organ transplant patients have an increased risk for infection and intestine and multivisceral patients are unique in that they often develop inflammation from rejection in the intestine which might predispose to infection.

*Methods: We reviewed patients who received an intestine transplant at three academic intestine transplant centers in the United States between 2010 and 2021 for demographic, laboratory and clinical data and outcomes.

*Results: Five patients were identified with diagnosis of adenovirus enteritis. Three patients (60%) had isolated intestine transplant while two underwent multivisceral transplant. Reason for transplant included trauma, volvulus, intestinal atresia and visceral neuropathy. All patients received induction with anti-thymocyte globulin thymoglobulin (80%) or basiliximab. The initial diagnosis of infection occurred at a mean of 26.8 months following transplant (range 2-68 months). Diagnosis was made by PCR measurement in plasma (80%), or inclusions on intestinal biopsy (20%). Cidofovir was used in 100% of cases as primary management. 40% of patients had reduction of immunosuppression at the time of diagnosis while the remainder did not. 60% of patients had rejection within a month prior to diagnosis. No patients had rejection within a month following treatment of the infection. Two patients had recurrent adenovirus infection following primary treatment. No patients had graft loss or death within 6 months following infection. Two patients had enterectomy at a mean of 29.5 months following infection (range 22-37 months) Three patients died at a mean of 32 months following diagnosis of AE (range 8-51 months).

*Conclusions: We present a series of patients with AE following intestinal or multivisceral transplant. AE may arise due to immunosuppression, vascular compromise of the transplanted organ, or a combination of factors. In our population, death or graft loss within six months was not seen following infection. Distinguishing the underlying causes and optimal treatment for AE in intestinal transplant patients may be achieved through larger studies.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Jafri S, Mavis A, Weiner J, Segovia MC. Adenovirus Enteritis Following Intestinal Transplantation [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/adenovirus-enteritis-following-intestinal-transplantation/. Accessed May 9, 2025.

« Back to 2022 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences