A Novel Nomogram-Based Approach for Defining the Effect of Transplantation on Cancer Recurrence Risk
1U of Cincinnati, Cincinnati
2Cleveland Clinic, Cleveland.
Meeting: 2018 American Transplant Congress
Abstract number: 268
Keywords: Kidney transplantation, Malignancy, Tumor recurrence
Session Information
Session Name: Concurrent Session: PTLD/Malignancies: All Topics
Session Type: Concurrent Session
Date: Monday, June 4, 2018
Session Time: 2:30pm-4:00pm
Presentation Time: 2:42pm-2:54pm
Location: Room 4C-4
The effect of transplantation on renal cell cancer (RCC) recurrence risk has not yet been precisely defined. Validated nomograms for predicting RCC recurrence risk (viz, Kattan nomograms) provide a unique opportunity for assessing effects of transplantation on cancer recurrence. We developed a novel approach for evaluation of the effect of transplantation on RCC recurrence by comparing actual RCC recurrence rates in transplant patients with rates predicted by the Kattan RCC recurrence risk nomogram. This approach, however, requires access to large numbers of patients with complete risk factor data.
Methods: Registry data were analyzed for patients with a history of RCC who were referred for transplantation between 1/1/2000 and 7/31/2012. Recurrence rates were defined by Kaplan Meier method and RCC recurrence risk factor data were entered into the Kattan nomogram model to provide predicted RCC recurrence rates.
Results: 213 patients with preexisting RCC were identified with complete predictor data (pathological stage, tumor size, patient symptoms, histology, Fuhrman grade, necrosis, and vascular invasion) for Kattan nomogram RCC recurrence risk estimation. Results are presented in the table for 213 patients. 
Observed RCC recurrence rates were statistically similar to nomogram-predicted RCC recurrence rates in the general population.
Figure 1: Actual Versus Nomogram Predicted RCC Recurrence Free Probability 
Conclusions: 1) Comparison of actual recurrence rates versus nomogram-predicted recurrence provides robust evidence indicating that the decision to proceed to transplantation does not affect RCC recurrence risk and 2) the nomogram-based approach provides a novel means for defining the effect of transplantation on cancer recurrence risk.
CITATION INFORMATION: Ejaz N., Alloway R., Paterno F., Singhal A., Ji X., Kattan M., Woodle E. A Novel Nomogram-Based Approach for Defining the Effect of Transplantation on Cancer Recurrence Risk Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Ejaz N, Alloway R, Paterno F, Singhal A, Ji X, Kattan M, Woodle E. A Novel Nomogram-Based Approach for Defining the Effect of Transplantation on Cancer Recurrence Risk [abstract]. https://atcmeetingabstracts.com/abstract/a-novel-nomogram-based-approach-for-defining-the-effect-of-transplantation-on-cancer-recurrence-risk/. Accessed November 21, 2024.« Back to 2018 American Transplant Congress