Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Introduction: Renal transplantation is the gold standard treatment for end-stage kidney disease. There are increased challenges in paediatric renal transplant recipients under 20kg, especially when placing an adult kidney into a small abdomen.
Methods: Data was retrieved from a prospectively collected database, electronic records and hospital notes from two Paediatric Transplant Units in UK. eGFR was calculated using the Schwartz formula (Schwartz GJ, Pediatrics 1976 ;58:259-63). Death-censored graft survival and patient survival were assessed using Kaplan-Meier analysis.
Results: 420 children, who had a kidney transplant between 2005-2015, were reviewed. Group A (<20kg) included 116 (28%) and Group B (>20kg) had 303 (72%) cases. The median age (years) for Group A was 3 (IQR 2-4) and for Group B, 13 (IQR 10-15). This was significantly different (p<0.001). 108 (93%) Group A cases had a functioning graft at last follow up (6 failed, 2 died) versus 274 (90%) Group B cases (29 failed, 1 died). 3 (38%) losses in Group A and 14 losses (48%) in Group B were due to rejection. The overall median follow up was 2 years (IQR 1-5) with a maximum of 9 years. The median donor age (years) was 37 (IQR 30-42) and 41 (IQR 34-47) for Group A and B respectively (p<0.001). Group A included 85 (73%) live, 28 DBD and 3 DCD donors and Group B 179 (59%) live, 116 DBD and 8 DCD donors. 1/116 in Group A and 29/303 in Group B were re-transplants. The last median eGFR was 61 (IQR 48-74) and 51 (IQR 40-63) in Group A and B respectively (p<0.001). There was no significance difference between the groups with respect to graft and patient survival (log rank test p=0.276 and 0.130 respectively).
Discussion: Despite the obvious difference in age between the two groups, the overall patient and graft survival was similar between children <20kgs and >20kgs in this cohort.Transplantation in small children is feasible with good outcomes.
CITATION INFORMATION: Chandak P, Stojanovic J, Jamshaid F, Mamode N, Calder F, Olsburgh J, Callaghan C, Drage M, Koffman G, Marks S, Kessaris N. A Decade of Paediatric Kidney Transplantation in Children Weighing <20kg. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Chandak P, Stojanovic J, Jamshaid F, Mamode N, Calder F, Olsburgh J, Callaghan C, Drage M, Koffman G, Marks S, Kessaris N. A Decade of Paediatric Kidney Transplantation in Children Weighing <20kg. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/a-decade-of-paediatric-kidney-transplantation-in-children-weighing-20kg/. Accessed June 6, 2020.
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