Mycophenolic acid(MPA) PK, from enteric-coated mycophenolate sodium(EC-MPS) has a broad range of Tmax avoiding the use a single concentration to calculate the area-under-the-time-concentration curve(AUC). Either for research or for clinical MPA monitoring, a complete AUC is troublesome for the patients(pts). We have developed abbreviated equations in 59 adult(54±16y) pts (29males,43whites) with 171 complete MPA-AUC_0-12h, under TAC/EC-MPS using 59 curves measured at mean of 31±4days after transplant, to develop the equations, and the remaining 112 performed at a mean of 109±59d for validation. We also compared our results with 5 other equations(4 with EMIT) available in the literature, comparing estimated AUC(eAUC) with measured AUC(mAUC), bias and 10%/30% accuracy. MPA was measured by UPLC MS-MS. EMIT data was transformed using Emit=1.012HPLC+0.244. The eAUCs that measure MPA up to 6hours, had an acceptable low bias with more results in the 10-30% range than those up to 4h. A highly adequate eAUC is obtained with 8h of blood collection. This analysis offers blood sampling alternatives depending on the precision needed.

CITATION INFORMATION: David-Neto E, Triboni A, Ramos F, Agena F, Romano P, Freitas G. A Critical Analysis of Equations for MPA Exposure in Patients Under EC-MPS and Tacrolimus. Am J Transplant. 2017;17 (suppl 3).

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