5-Year Serum Alkaline Phosphatase Levels after Kidney Transplantation is Associated with Long-Term Graft Survival and Mortality in Kidney Recipient
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
2Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
3The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
Meeting: 2018 American Transplant Congress
Abstract number: A197
Keywords: Graft failure, Kidney transplantation, Mortality
Session Information
Session Name: Poster Session A: Kidney: Cardiovascular and Metabolic
Session Type: Poster Session
Date: Saturday, June 2, 2018
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall 4EF
Background: Previous studies have attempted to identify risk factors of renal graft injury that can be used to improve long-term graft survival. Recently, higher serum alkaline phosphatase (ALP) concentrations have been shown to associate with higher risks for mortality in chronic kidney disease patients.
The present study examined whether the serum ALP levels of post-transplantation during the five years is an important risk factor for long-term graft survival of kidney transplantation (KT) patients.
Methods: We included 1,606 adult recipients who underwent KT in single center with more than 5 YR follow-up period. The level of serum ALP were obtained preoperatively, and then annually throughout study period. Covariates in cox-regression model included dialysis duration before KT, recipient age and sex, related status, acute rejection status, hepatitis, diabetes status, renal function at 1 year after KT and pre-transplant serum ALP. The mean ALP levels between 1 to 5 years after KT (5YR-ALP) were divided into quartiles.
Results: Mean graft survival and patient's survival was significantly lower in the 3rd and highest quartile of 5YR-ALP group than the 1st and 2nd quartile groups. Graft survival rate estimated by Kaplan-Meier estimator was significantly lower in thehighest quartile of 5YR-ALP group (log-rank test p=.004).
The multivariable Cox regression adjusting covariates including pre-transplant ALP showed that the highest quartile of 5YR-ALP group has the significant association with higher graft failure (HR=2.619, p=.002) and mortality ((HR=3.476, p=.010).
Conclusion: Our data support that the higher mean ALP between 1 to 5 years after KT is associated with poor outcome for long-term kidney graft survival and mortality in KT recipients.
CITATION INFORMATION: Choi H., Kim D., Huh K., Kim Y., Kim B. 5-Year Serum Alkaline Phosphatase Levels after Kidney Transplantation is Associated with Long-Term Graft Survival and Mortality in Kidney Recipient Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Choi H, Kim D, Huh K, Kim Y, Kim B. 5-Year Serum Alkaline Phosphatase Levels after Kidney Transplantation is Associated with Long-Term Graft Survival and Mortality in Kidney Recipient [abstract]. https://atcmeetingabstracts.com/abstract/5-year-serum-alkaline-phosphatase-levels-after-kidney-transplantation-is-associated-with-long-term-graft-survival-and-mortality-in-kidney-recipient/. Accessed May 16, 2025.« Back to 2018 American Transplant Congress