Background: Microscopic hematuria is not uncommon in potential kidney donors. After excluding urological causes, most of these donors require kidney biopsy to exclude glomerular lesions. We evaluated biopsy findings among donors with isolated microscopic hematuria and assessed short-term outcomes of their prospective recipients. Methods: kidney donors between Jan 2010 & Jan 2015 who had isolated microscopic hematuria were included in the study. All of them underwent native kidney biopsies which were examined by light microscopy,immunofluorescence and electron microscopy. Predonation characteristics were compared between donors with normal & abnormal biopsies. Short-term outcomes of donors were compared to 27age matched nonhematuric donors as a control group at 3 month post donation.Results: Out of 750 donors, 27 donors (3.6%) were found to have isolated microscopic hematuria & underwent kidney biopsy. Mean age was 32.6±8,all of these donors had positive dipstick hematuria in urine & minimum of 3 red blood cells/hpf on urine microscopy. Eight (29.6%) biopsies showed histopathological abnormalities of which, thin basement membrane disease (n=6, 22.2%) was the commonest lesion followed by IgA nephropathy (n=2, 7.4 %). Donors with abnormal biopsy findings were excluded from donation. The remaining (n=19, 70.4%) had no significant pathology and were permitted to donate. Except for 2 donors (7.4%) who were excluded due to other medical/recipient related issues. There was no significant difference in short-term outcomes between hematuric and nonhematuric donors accepted for donation at 3 month post donation. The recipients of kidneys from hematuric donors with no histopathological abnormalities had a mean SBP of 121 ± 9.5, mean DBP 74 ±8.5 and mean serum creatinine of (75.6[micro]mol/l±21.3) at three month follow up with no rejection episodes. Conclusions: Our study showed that 29.6 % of our donors with isolated microscopic hematuria had abnormal histopathology on renal biopsy. Isolated asymptomatic microscopic hematuria justifies extensive work up including renal biopsy to identify donors who may have underlying renal pathology before accepting them for donation.

CITATION INFORMATION: Hassan E, Aleid H, Zulfiquar T, Ibrahim I, Almana H. Potential Kidney Donors with Asymptomatic Micorsocpic Hematuria: Histopathological Findings & Outcomes. Am J Transplant. 2016;16 (suppl 3).

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