Pretransplant Hepatitis B Viral Infection Increased Risk of Death After Kidney Transplantation

J. Lee,¹ J.-H. Cho,² J. An,³ C.-D. Kim,² C. Ahn,⁴ I. Jung,³ D. Han, C. Lim,³ Y. Kim,⁴ Y. Kim, J. Lee.³

¹Internal Medicine, Hallym University Hangang Sacred Heart Hospital, Seoul, Republic of Korea
²Internal Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea
³Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea
⁴Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
⁵Surgery, Ulsan University Seoul Asan Medical Center, Seoul, Republic of Korea.

Meeting: 2015 American Transplant Congress

Abstract number: B122

Keywords: Graft failure, Hepatitis B, Hepatitis C, Survival

Session Information

Session Name: Poster Session B: Kidney Complications: Late Graft Failure

Session Type: Poster Session

Date: Sunday, May 3, 2015

Session Time: 5:30pm-6:30pm

Presentation Time: 5:30pm-6:30pm

Location: Exhibit Hall E

Clinical outcomes have not been well evaluated in kidney transplant recipients (KTRs) with hepatitis B virus (HBV). Here, we aimed to investigate the recent posttransplant clinical outcomes in an HBV endemic country.

Among 4897 Korean kidney recipients from Aril 1999 to December 2011, 4412 patients whose viral hepatitis serology data was available were enrolled. Numbers of patients with HBV and hepatitis C virus (HCV) were 209 (4.7%) and 83 (1.9%).We analyzed the clinical outcomes, including overall mortality, graft failure, and new-onset diabetes after transplantation (NODAT), among patients who had taken kidney transplantation.

Patients with HBV showed poorer survival than KTRs without HBV or HCV (P = 0.004, HR = 2.084, 95% CI 1.266-3.430). However HCV did not affect patient survival (P = 0.119, HR = 1.914, 95% CI 0.846-4.327). Patients with chronic hepatitis C showed increased incidence of graft failure (P < 0.001, HR = 2.271, 95% CI 1.481-3.480). The graft survival of patients with chronic hepatitis B was not different (P = 0.773, HR = 1.082, 95% CI 0.634-1.846) compared with the seronegative patients. Incidence of NODAT was not increased in patients with chronic hepatitis B (P = 0.493, OR 1.180, 95% CI 0.734-1.897), but increased in patients with chronic hepatitis C (P = 0.041, OR 1.993, 95% CI 1.027-3.869). Among causes of patient mortality in chronic hepatitis B, hepatic causes were more prominent (1 hepatic failure, 2 hepatocellular carcinoma; 20.0% vs. 0.8%, P < 0.001) compared with patients without chronic hepatitis B. Patients with chronic hepatitis C and allograft failure showed increased trend of transplant rejection (83.3% vs. 68.6%, P = 0.462), but the statistical significance was not proved. Pretransplantation liver biopsy and hepatitis B/C viral titer were not associated with post transplantation patient survival or graft loss.

Kidney transplantation recipients with chronic hepatitis B could show poor survival due to post transplantation hepatic complications.

To cite this abstract in AMA style:

Lee J, Cho J-H, An J, Kim C-D, Ahn C, Jung I, Han D, Lim C, Kim Y, Kim Y, Lee J. Pretransplant Hepatitis B Viral Infection Increased Risk of Death After Kidney Transplantation [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/pretransplant-hepatitis-b-viral-infection-increased-risk-of-death-after-kidney-transplantation/. Accessed November 21, 2024.

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