Hyperuricemia Takes a Toll in Graft Function, Left Ventricular Diameters and Arterial Stiffness in Renal Transplant Recipients
1Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey
2Department of Internal Medicine, Baskent University Faculty of Medicine, Ankara, Turkey
3Department of General Surgery, Baskent University Faculty of Medicine, Ankara, Turkey.
Meeting: 2015 American Transplant Congress
Abstract number: A183
Keywords: Graft function, Kidney transplantation, Metabolic complications
Session Information
Session Name: Poster Session A: Kidney: Cardiovascular and Metabolic
Session Type: Poster Session
Date: Saturday, May 2, 2015
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Exhibit Hall E
Purpose: Cardiovascular diseases are the leading cause of morbidity and mortality in renal transplant recipients (RTRs). Serum uric acid (UA) levels correlate with many recognized cardiovascular risk factors, as hypertension, hypertriglyceridemia and insulin resistance. The impact of serum UA on outcomes of RTRs remains controversial. The aim of this study was to evaluate the relation between serum UA, graft function and arterial stiffness accompanied by echocardiographic measurements.
Materials and Methods: We performed a cross-sectional observational study of 118 hyperuricemic (serum UA were ≥ 4 mg/dl) maintenance RTRs with stable allograft function at the first year of transplantation. All acute cellular and humoral rejections were excluded. All patients were evaluated for their standard clinical (age, gender, post-transplant time), biochemical parameters. PWv was determined from pressure tracing over carotid and femoral arteries using the SphygmoCor system. We calculated the estimated GFR (eGFR) using the MDRD4 equation. Rutine first years transthorasic echocardiographic measurements (ejection fraction (EF), left ventricular end-diastolic diameter (LVDD), left ventricular end systolic diameter (LVSD)) was recorded.
Results: All patients were similar in means of clinical demographic characteristics. Mean serum UA level was 5.7±1.5 mg/dl. A significant positive correlation was found between serum UA and PWv (r: 0.396, p: 0.01), systolic blood pressure (r: 0.312, p: 0.001), LVSD (r: 0.275, p: 0.05), LVDD (r: 0.303, p: 0.01), however an invers correlation was detected between serum UA levels and eGFR (r: -0.530, p: 0.01). ). For each 1 mg/dl of increased level of UA resulted in 0.6 cm/sec of increased level of PWv (p: 0.001), 0.078 cm of LV systolic diameter (p: 0.013) and 0.06 cm of LVDD (p: 0.005), besides 9.6 ml/min of decreased level in eGFR (p: 0.01). In lineer regression analysis, serum UA (p: 0.001), C-reactive protein (p: 0.024), EF (p: 0.001) and LVDD (p: 0.033) were detected as the predictors of eGFR.
Conclusions: Present study concluded that hyperuricemia can contribute to cardiovascular morbidity and mortality by vascular damage and deteriorating left ventricular functions together with impairing graft function.
To cite this abstract in AMA style:
Demirci BGurlek, Sezer S, Oygur C, Bal Z, Tutal E, Haberal M. Hyperuricemia Takes a Toll in Graft Function, Left Ventricular Diameters and Arterial Stiffness in Renal Transplant Recipients [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/hyperuricemia-takes-a-toll-in-graft-function-left-ventricular-diameters-and-arterial-stiffness-in-renal-transplant-recipients/. Accessed November 24, 2024.« Back to 2015 American Transplant Congress