Analysis of Antibiotic Resistance and Risk Level of Preservation Fluid Microorganisms in Kidney Transplant Recipients

J. Li¹, X. Su¹, J. Han², Y. Huang², W. Wu¹, M. Wei², S. Yuan², C. Wu¹, J. Li¹, L. Liu¹, C. Wang¹

¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Sun Yat-sen University, Guangzhou, China

Meeting: 2022 American Transplant Congress

Abstract number: 1001

Keywords: Infection, Kidney transplantation, Preservation solutions

Topic: Clinical Science » Infection Disease » 25 - Kidney Infectious Non-Polyoma & Non-Viral Hepatitis

Session Information

Session Name: Kidney Infectious Non-Polyoma & Non-Viral Hepatitis

Session Type: Poster Abstract

Date: Sunday, June 5, 2022

Session Time: 7:00pm-8:00pm

Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: As a solution for preserving kidney during procurement and transportation, preservation fluid (PF) is the main method to detect donor-derived infection. But there are few studies analyzing the risk level of microorganisms in PF. Antibiotic resistance of microorganisms in PF is also rarely described.

*Methods: A retrospective study involving 808 kidney transplant recipients from The First Affiliated Hospital of Sun Yat-sen University between April 2015 to October 2020 was conducted. Exclusion criteria included the absence of preservation fluid and living donor transplants. The microbiological distribution, antibiotic resistance and early postoperative infections including donor-derived infections (DDI) were analyzed. ESKAPE is an acronym comprising the scientific names of six highly virulent and antibiotic resistant bacterial pathogens.

*Results: The total positive rate of PF was 40.7% (329/808) and the main microorganism was coagulase-negative Staphylococci (34.49%). Moreover, higher incidence of bloodstream infection (P=0.006) and perirenal infection (P=0.004) was found in the PF positive group. In the meantime, the antibiotic resistance rate was up to 54.4% (179/329) and the early postoperative infections and DDI were more likely to occur in the antibiotic resistant group. Among the 329 patients, ESKAPE group accounted for 31.6% (104), Candida group accounted for 9.7% (32), ESKAPE and Candida group accounted for 6.1% (20), and other microorganisms accounted for 52.6% (173). Furthermore, we identified 7 patients with DDI (2.1%). We found that DDI (P=0.005), bloodstream infection (P=0.033) and perirenal infection (P=0.000) were more likely to occur in ESKAPE or Candida groups compared to other microorganisms groups. Interestingly, the incidence of DDI in ESKAPE group with extensively drug resistant was up to 13.2%.

*Conclusions: PF positive is significant in the occurrence of early postoperative infections, especially in perirenal infection and bloodstream infection and antibiotic resistance microorganisms need to be concerned. Also, ESKAPE or Candida have a higher risk of DDI transmission, which requires more attention.

To cite this abstract in AMA style:

Li J, Su X, Han J, Huang Y, Wu W, Wei M, Yuan S, Wu C, Li J, Liu L, Wang C. Analysis of Antibiotic Resistance and Risk Level of Preservation Fluid Microorganisms in Kidney Transplant Recipients [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/analysis-of-antibiotic-resistance-and-risk-level-of-preservation-fluid-microorganisms-in-kidney-transplant-recipients/. Accessed November 23, 2024.

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