*Purpose: Recent advancements in cancer treatment and post-transplant management have allowed for a wider population of living donor transplant candidates. We employed a national survey to examine variations in public acceptance of living donor liver transplant based on patient diagnosis, including colorectal liver metastases (CRLM).

*Methods: ResearchMatch, a secure, online tool was used to recruit adult, English speaking volunteers in the United States. A web-based survey collected demographic information, general perceptions on organ donation and presented respondents with eight scenarios in which they indicated their likelihood to be living liver donor for family member with: genetic liver disease, alcohol-related liver disease and CRLM, noting that this disease has up to a 50% recurrence rate in the first year post-transplant. Summary statistics describe the study sample, the Wilcoxon Signed-Rank Test was used to compare differences in likelihood of donation across scenarios.

*Results: There were 491 survey respondents; subjects were predominantly female (76.5%), White (85.6%) and had at least a college degree (84.1%). Most respondents (82.4%) were aware of the option of living liver donation prior to the study and 95% supported living organ donation in general. Over 80% of respondents were registered organ donors.Nine of ten survey respondents indicated that they would be likely to donate to a family member with a genetic disease if they qualified as a living donor; significantly more so than all other scenarios [figure]. Willingness to donate to CRLM patients was statistically significantly higher than the hypothetical patient with alcohol-related liver disease and the clinically accepted cessation period of 6 months.

*Conclusions: The majority of our respondents were likely to be a living donor for all indications presented; including CRLM. Further surveys with a broader respondent pool are warranted.

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