*Purpose: Cirrhosis is a common disease however it is understudied because population data on patients with cirrhosis is lacking. While the risk of hospitalization in the general population in 2017 was 6.5% per year and in patients 85 yrs or above was 22% per year, little is known about the risk for hospitalizations in patients with cirrhosis. We used National Patient-Centered Clinical Research Network (PCORnet) data to examine this question.

*Methods: PCORnet data from two centers between 2012-2018 were used and patients with cirrhosis were identified through an algorithm of ICD-9, ICD-10, or RXCUI codes. Only adult patients (>18yrs) were included. Demographics were assessed and hospitalizations were calculated.

*Results: 62,580 patients with cirrhosis were identified with 87,489 patient-years of follow up. Patients mean age was 51.25 yrs, 38.2% were Female, 38.3% were White, and 51.6% were Black. The mean MELD-Na was 11.0.During the study period patients had 171,397 emergency visits and underwent 41,643 admissions, or 45.6 hospitalizations per 100 patient-years of follow up. Patients were admitted for a total of 330,469 days (904.8 patient-years) or 1.03 days admitted per 100 days of follow up. Patients with cirrhosis had a seven times higher rate of hospitalization than the general population and a 2.1 times higher rate than patients over 85 years old, the highest risk subset of the general population.

*Conclusions: Hospitalizations are very frequent in patients with cirrhosis. Large datasets may provide insight into prevention of hospitalizations.

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