Outcomes of Simultaneous Pancreas and Kidney Transplantation Based on Donor Resuscitation

F. Messner¹, J. W. Etra², Y. Yu³, K. Jackson², A. B. Massie², G. Brandacher², S. Schneeberger⁴, C. Margreiter⁴, D. L. Segev²

¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, ⁴Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria

Meeting: 2020 American Transplant Congress

Abstract number: 402

Keywords: Donors, unrelated, Graft survival, Pancreas transplantation, Pancreatitis

Session Information

Session Name: Pancreas and Islet: All Topics I

Session Type: Oral Abstract Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:45pm

Presentation Time: 4:15pm-4:27pm

Location: Virtual

*Purpose: It has been hypothesized that transplanting simultaneous pancreas kidney (SPK) grafts from donors with a history of cardiac arrest and cardiopulmonary resuscitation (CACPR) leads to inferior post-transplant outcomes due to organ hypoperfusion during cardiac arrest and mechanical trauma during resuscitation.

*Methods: Using SRTR national registry data, we identified 13,095 SPK transplants 2000-2018. We compared graft and patient survival between recipients of CACPR vs non-CACPR donors using Cox regression and inverse probability weighting to account for covariate imbalance. For secondary outcome variables weighted logistic regression or the logrank test were used.

*Results: 1-, 5- and 10-year patient (CACPR: 96.4%, 89.9%, 78.9%; non-CACPR: 96.3%, 88.9%, 76.0%; p=0.3), death-censored pancreas graft survival (CACPR: 89.3%, 82.7%, 75.0%; non-CACPR: 89.9%, 82.7%, 76.3%; p=0.7), and death-censored kidney graft survival (CACPR: 97.0%, 89.5%, 78.2%; non-CACPR: 96.9.9%, 88.7%, 80.0%; p=0.4) were comparable between the two groups. Both groups displayed a similar rate of postoperative graft pancreatitis (CACPR: 2.9%, non-CACPR: 2.4%; p=0.4), anastomotic leak (CACPR: 1.6%, non-CACPR: 2.0%; p>0.9), or median length of hospital stay (CACPR: 8 days, non-CACPR: 9 days; p=0.6).

*Conclusions: Our findings suggest that CACPR donors can be used to expand the SPK donor pool without compromising short or long-term outcomes.

To cite this abstract in AMA style:

Messner F, Etra JW, Yu Y, Jackson K, Massie AB, Brandacher G, Schneeberger S, Margreiter C, Segev DL. Outcomes of Simultaneous Pancreas and Kidney Transplantation Based on Donor Resuscitation [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/outcomes-of-simultaneous-pancreas-and-kidney-transplantation-based-on-donor-resuscitation/. Accessed November 22, 2024.

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