*Purpose: 0 0 1 323 1842 Indiana University 15 4 2161 14.0 Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:”Table Normal”; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:”; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:Cambria; mso-ascii-font-family:Cambria; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Cambria; mso-hansi-theme-font:minor-latin;} Nephrolithiasis is considered at least a relative contraindication to living donor nephrectomy. More centers have started accepting donor-gifted lithiasis but data on long-term safety is limited. Long-term outcomes for recipients from a single transplant center are presented.

*Methods: Living donors with a history of stone passage or computerized tomographic (CT) evidence of nephrolithiasis and those who underwent nephrectomy between 2003 and 2018 were identified. Data were obtained on donors and recipients through retrospective review of organ transplant registry data. Risk factors for stone formation noted in 24-hour urine studies are defined. Long terms outcomes for stone recurrence and graft function are reported.

*Results: RESULTS: Between 2003 and 2018, 57 donor-recipient pairs were identified. Mean age of donors was 43±10 years while recipients were older with mean age 46±19 years. The population was predominantly white (>90%). Females comprised 73.6 % and 42.1 % of donors and recipients respectively. A pre operative 24-hour urine collection was available for 53 (92.9%) donors. Hyperoxaluria and hypercalciuria (11/53 each) followed by hypocitraturia (9/53 each) were common predisposing factors. Abnormal urinary pH was noted in 39.9 % of patients. Six donors had previous symptomatic nephrolithiasis. The median stone size was 2 mm (range 1-6 mm). More than one calculus was noted in 19.3% of the donated kidneys, while bilateral stones were noted in 1 patient. Left side donor nephrectomy was performed in 32 (56%) of the donors. Median follow up for recipients was 3.5 (IQR 1.5-7.1) years. Imaging of the transplant kidney was available in 34 patients (US=21, CT-13) at a median follow up of 2.0 (IQR 0.4-4.0) years. Three recipients had evidence of nephrolithiasis (bladder = 1, asymptomatic but imaging evidence=2). None of the recipients had obstructing renal calculi and no infections related to nephrolithiasis were reported.

*Conclusions: Donor-gifted lithiasis is noted to be safe for recipients in this long term follow up study. Donors with small (<4 mm) calculi and mild metabolic derangements should be considered for nephrectomy.

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