Association Of Kdpi And Dgf With Dcd Kidney Transplants Outcomes
David Geffen Sch of Med at UCLA, Los Angeles, CA
Meeting: 2019 American Transplant Congress
Abstract number: 413
Keywords: Allocation, Donors, non-heart-beating, Graft failure, Kidney transplantation
Session Information
Session Name: Concurrent Session: Kidney Complications: Late Graft Failure III
Session Type: Concurrent Session
Date: Tuesday, June 4, 2019
Session Time: 2:30pm-4:00pm
Presentation Time: 3:06pm-3:18pm
Location: Veterans Auditorium
*Purpose: Donors of circulatory death (DCD) have similar outcomes compared to donors of brain death (DBD) in kidney transplants. It is unclear if this is also true across KDPI range.
*Methods: Data from UNOS/OPTN as of 05/2018 was used to examine DCD vs. DBD outcomes across the KDPI. Deceased donor adult recipients from 2015-18 (n=38,780) were stratified in DCD(n=8,207) and DBD (30,572). Primary non-function (PNF), delayed graft function (DGF), 3-year death censored graft failure (DCGF) and patient death (PD) were examined using percentages, adjusted logistic and cox regression.
*Results: Groups differed in all demographic and transplant baseline characteristics. PNF and DGF risk were increased in DCD vs. DBD, odds ratio (OR) 1.19(95%CI,1.11-1.28) and 3.23(3.04-3.44); while DCGF and PD risk were similar, hazard ratio (HR) 0.97(0.84-1.11) and 0.96(0.84-1.09), respectively. In DBD the prevalence of DGF increased the highest the KDPI, and in DCD it seems to plateau around 50% with KDPI > 70% (figure 1 – graphs). OR to DGF varied from 2.2-2.6 and HR to DCGF was not significant different in DCD vs. DBD across KDPI intervals (table 1). A sub-analysis compared DCD groups stratified by KDPI < or > 85%, and DGF (table 2).
*Conclusions: DCD compared to DBD was associated with increased risk of DGF, but similar 3-year DCGF. A higher KDPI did not modify DGF and DCGF risks when comparing DCD vs. DBD. DGF increased risk of DCGF in DCD transplants independent of KDPI.
To cite this abstract in AMA style:
Sampaio M, Abdalla B, Bunnapradist S. Association Of Kdpi And Dgf With Dcd Kidney Transplants Outcomes [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/association-of-kdpi-and-dgf-with-dcd-kidney-transplants-outcomes/. Accessed November 22, 2024.« Back to 2019 American Transplant Congress