Higher Concordance in the Incidence of DGF and Post-Transplant BKV Infection among Recipients Receiving Mate Kidneys from the Same Deceased Donor: A Paired Deceased Donor Kidney Transplant Analysis
1Nephrology Division, Univ of Pittsburgh Medical Center, Pittsburgh, PA
2Transplant Surgery, Univ of Pittsburgh Medical Center, Pittsburgh, PA.
Meeting: 2018 American Transplant Congress
Abstract number: C185
Keywords: Cadaveric organs, Kidney transplantation, Outcome, Polyma virus
Session Information
Session Name: Poster Session C: Kidney: Polyoma
Session Type: Poster Session
Date: Monday, June 4, 2018
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
Background: This study was undertaken to explore the degree to which donor variables impact rates of DGF, post-transplant CMV and BKV infections using a paired deceased donor (DD) kidney transplant analysis . Methods: The outcomes of 188 DD kidney transplants (94 pairs: Group IA-Right and Group IB-Left) from Jan2013-Dec2015 were compared. In addition, they were also compared to a control of 161 solitary kidneys (Group II) transplanted at our center from 161 DD. Demographics, incidence of DGF, post-transplant CMV/BKV infection were compared (IA vs.IB)/(I vs. II). We used the Kappa statistic to analyze the occurrence of shared and discordant events (DGF, CMV and BKV). Results: Baseline demographics (age,sex,race) and Recipient variables (BMI, Class I/II PRA%, CMV/EBV status) were similar between groups. Transplant variables (DBD/DCD, KDPI, CIT), and post-transplant (DGF, BKV and CMV infection) outcomes among DD recipients (GR IA vs.IB; GRI vs II) were similar.
| Gr IA DD: Right Kidney[n=94] | Gr IB: DD: Left Kidney [n=94] | P:Gr 1A vs.IB | Gr i: DD Rt and Lt Kidney Combined (n=188) | Gr II: DD only 1 kidney transplanted, [n=161] | P:Gr 1 vs. II | |
| CITmin:Mean,SD | 675+280 | 616+279 | 0.1528 | 646+282 | 625+292 | 0.4856 |
| Donor%:DBD/DCD | 64/36 | 64/36 | 1.0 | 64/36 | 77/23 | 0.2187 |
| KDPI%:mean,SD | 48+22 | 48+22 | 1.0 | 48+22 | 46+23 | 0.0283 |
| DGF: N/% | 28(29) | 21(22) | 0.2465 | 49(26) | 29(18) | 0.0648 |
| Plasma BKVDNA>5000 copies/ml) within 1year: N/% | 9(10) | 9(10) | 1.0 | 18(10) | 20(12) | 0.8253 |
Analysis revealed that a total of 13/21 recipients had DGF and 4/9 had BKV infection in both Gr IA and IB. Kappa values were 0.37 for DGF, 0.1 for CMV viremia, and 0.39 for BK viremia>5000 copies/mL. The strength of agreement was fair for both DGF and BKV infection and was poor for CMV infection among same DD paired kidney recipients. Conclusion: We conclude that higher concordance between same-donor recipient pairs for DGF and Post-transplant BKV infection suggests that donor variables influences the occurrence of DGF, and the source of infection in BK is possibly donor in origin.
CITATION INFORMATION: Venkatesh K., Wu C., Puttarajappa C., Mehta R., Sood P., Tevar A., Hariharan S. Higher Concordance in the Incidence of DGF and Post-Transplant BKV Infection among Recipients Receiving Mate Kidneys from the Same Deceased Donor: A Paired Deceased Donor Kidney Transplant Analysis Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Venkatesh K, Wu C, Puttarajappa C, Mehta R, Sood P, Tevar A, Hariharan S. Higher Concordance in the Incidence of DGF and Post-Transplant BKV Infection among Recipients Receiving Mate Kidneys from the Same Deceased Donor: A Paired Deceased Donor Kidney Transplant Analysis [abstract]. https://atcmeetingabstracts.com/abstract/higher-concordance-in-the-incidence-of-dgf-and-post-transplant-bkv-infection-among-recipients-receiving-mate-kidneys-from-the-same-deceased-donor-a-paired-deceased-donor-kidney-transplant-analysis/. Accessed November 21, 2024.« Back to 2018 American Transplant Congress