Pancreas outcomes in pancreas after kidney transplantation have been reported as being inferior to those from simultaneous pancreas-pancreas (SPK). The influence of kidney donor (living- vs deceased-donor) has never been previously addressed. We retrospectively analyzed all pancreas transplants performed in a single center since 2007, and compared the outcomes from those who had previously received a living-donor kidney transplant (PAldK; n=18) or a deceased-donor kidney transplant (PAddK; n=28), using SPK (n=139) recipients as reference. Pancreas survival was similar between all groups, but inferior for PAldK when included only those with functioning graft at day 90 post-transplant (p=.004). Pancreas acute rejection was significantly increased in PAldK (67%; 1,8±1,4 episodes/graft) when compared to PAddK (25%) and SPK (32%) (p<.05; figure1). In a multivariate Cox regression model including known risk factors for pancreas rejection, PAldK was the only predictor of acute rejection (HR 6,82 95% CI 1,51-30,70, p<.05). No association was found between donor-recipient HLA mismatches and graft rejection. Repeated HLA incompatibilities between kidney and pancreas donors (0 vs 1-6) did not correlate with pancreas graft rejection or survival in both PAK groups (p>.05). In conclusion, pancreas graft outcomes are worse for PAldK when compared to PAddK and SPK.

CITATION INFORMATION: Ventura-Aguiar P., Ferrer J., Revuelta I., Paredes D., De-Sousa E., Rovira J., Esmatjes E., Garcia-Valdecasas J., Oppenheimer F., Diekmann F., Ricart M. Pancreas Outcomes between Living and Deceased Kidney Donor Recipients in Pancreas after Kidney Transplantation Am J Transplant. 2017;17 (suppl 3).

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