Portal Vein Thrombosis (PVT) in Liver Transplantation – Recent Experience
Ochsner Multi-Organ Transplant Institute, Ochsner Medical Center, New Orleans, LA.
Meeting: 2018 American Transplant Congress
Abstract number: A237
Keywords: Liver transplantation, Portal veins, Post-operative complications
Session Information
Session Name: Poster Session A: Liver Retransplantation and Other Complications
Session Type: Poster Session
Date: Saturday, June 2, 2018
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall 4EF
From 01-Nov-2012 to 31-Oct-2017, 1025 liver transplants were done at our center. Excluding retransplants and combined liver-kidney transplants, 830 transplants were studied for this abstract to determine outcomes in patients with complete (n = 27) or partial (n = 67) PVT at time of OLT. Inflow was restored with thromboendvenectomy in all except one patient with a SMV jump graft. Patients received aspirin but no other anticoagulation. Doppler ultrasound was done on days 1 and 7, and as clinically indicated.
Donor and Recipient Characteristics:
(all values medians) | Patent | Partial PVT | Complete PVT |
n | 736 | 67 | 27 |
Recipient Age | 58 | 61 | 60 |
MELD-Na at Txp | 19 | 20 | 18 |
Donor Age | 47 | 45 | 45 |
DRI | 1.605 | 1.480 | 1.485 |
DCD % | 12 | 12 | 12 |
Cold Ischemia (min) | 313 | 336 | 312 |
Warm Ischemia (min) | 29 | 32 | 29 |
Local OPO % | 43 | 48 | 41 |
Results:
(all values medians) | Patent | Partial PVT | Complete PVT |
n | 736 | 67 | 27 |
Post-Txp Length of Stay | 8 | 9 | 11 |
IntraOperative RBC Transfusion | 2 | 3 | 4 |
Procedure Duration | 287 | 307 | 310 |
Patient Survival 1 year | 93.9% | 87.2% | 79.9% |
Patient Survival 3 year | 88.3% | 73.8% | 74.9% |
Graft Survival 1 year | 91.9% | 82.7% | 72.7% |
Graft Survival 3 year | 86.3% | 69.2% | 67.8% |
All patent vs. partial patent differences p = NS; for patent vs. full PVT, p < 0.05 (procedure time), p < 0.01 (RBC use), p < 0.001 (LOS). No patient had recurrent PVT.
Discussion
OLT in the setting of PVT can be done in nearly all cases without the need for jump grafts. Immediate outcomes are very similar to controls, but 1- and 3-yr survival is decreased. RBC use, procedure duration, and hospital stay are increased by complete PVT but much less so by partial PVT. The late differences in survival were not attributable to recurrent PVT in this series. While less than that of controls, long-term survival was obtained in over two-thirds of recipients with PVT.
CITATION INFORMATION: Bruce D., Bohorquez H., Seal J., Cohen A., Bugeaud E., Carmody I., Sonnier D., Mathur A., De Gregorio L., Sharma H., Loss G. Portal Vein Thrombosis (PVT) in Liver Transplantation – Recent Experience Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Bruce D, Bohorquez H, Seal J, Cohen A, Bugeaud E, Carmody I, Sonnier D, Mathur A, Gregorio LDe, Sharma H, Loss G. Portal Vein Thrombosis (PVT) in Liver Transplantation – Recent Experience [abstract]. https://atcmeetingabstracts.com/abstract/portal-vein-thrombosis-pvt-in-liver-transplantation-recent-experience/. Accessed November 23, 2024.« Back to 2018 American Transplant Congress