Ubiquitous expression of vitamin D receptors on antigen-presenting cells has sparked interest into its immunomodulatory effects. While previous literature has described the effect of vitamin D on graft function, the impact on immunologic outcomes has yet to be explored. The purpose of this study was to evaluate an association between vitamin D levels and immune-mediated graft function. We performed a single-center review of 125 kidney transplant recipients (KTRs) from 2014-2016. All KTRs were discharged on ergocalciferol 50,000 units weekly. KTRs were categorized as deficient (<20 ng/mL), insufficient (20-30 ng/mL), or sufficient (>30 ng/mL). Immune-mediated graft function was measured by a composite of immunologic graft loss, acute rejection, and de novo donor specific antibodies (dnDSAs) at 1 year post-transplant. Baseline demographics were similar, with the exception of more males in the sufficient group (Table 1). Overall rates of rejection and dnDSAs were 14% and 17% respectively, with no graft losses. Rates did not differ significantly between groups (Table 2). Compared to KTRs with sufficient 25(OH)D levels at 1 month, insufficient (OR=1.3, 95%CI 0.4 to 3.7, p=0.68) and deficient (OR=1.1, 95%CI 0.4 to 3.2, p=0.84) 25(OH)D levels were not associated with the composite outcome at 1 year post-transplant using unadjusted logistic regression. Our preliminary data suggests no correlation between vitamin D levels and graft outcomes at 1 year post-transplant, though larger studies are warranted.

CITATION INFORMATION: Pham C., Pierce B., Bapat S., Kuten S., Moore L., Gaber A. Impact of Vitamin D Status on Immune-Mediated Graft Function Following Kidney Transplantation Am J Transplant. 2017;17 (suppl 3).

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